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Titolo:
Natural killer cells lyse autologous herpes simplex virus infected targetsusing cytolytic mechanisms distributed clonotypically
Autore:
Pietra, G; Semino, C; Cagnoni, F; Boni, L; Cangemi, G; Frumento, G; Melioli, G;
Indirizzi:
Ist Nazl Ric Canc, Ctr Biotecnol Avanzate, Sez Aggregata Immunoterapia Cellulare, I-16132 Genoa, Italy Ist Nazl Ric Canc Genoa Italy I-16132 ia Cellulare, I-16132 Genoa, Italy Ist Nazl Ric Canc, Serv Epidemiol Clin, I-16132 Genoa, Italy Ist Nazl Ric Canc Genoa Italy I-16132 idemiol Clin, I-16132 Genoa, Italy Ist Nazl Ric Canc, Serv Immunogenet, I-16132 Genoa, Italy Ist Nazl Ric Canc Genoa Italy I-16132 Immunogenet, I-16132 Genoa, Italy
Titolo Testata:
JOURNAL OF MEDICAL VIROLOGY
fascicolo: 3, volume: 62, anno: 2000,
pagine: 354 - 363
SICI:
0146-6615(200011)62:3<354:NKCLAH>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-I MOLECULES; NK CLONES; HLA-A; INHIBITORY RECEPTORS; HEAVY-CHAINS; RECOGNITION; EXPRESSION; SPECIFICITY; PROTECTION; SUSCEPTIBILITY;
Keywords:
killer-cell inhibitory receptors; killer-cell activating receptors; natural killer cell clones;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Melioli, G Ist Nazl Ric Canc, Ctr Biotecnol Avanzate, Sez Aggregata Immunoterapia Cellulare, Largo Rosanna Benzi 10, I-16132 Genoa, Italy Ist Nazl Ric Canc Largo Rosanna Benzi 10 Genoa Italy I-16132 y
Citazione:
G. Pietra et al., "Natural killer cells lyse autologous herpes simplex virus infected targetsusing cytolytic mechanisms distributed clonotypically", J MED VIROL, 62(3), 2000, pp. 354-363

Abstract

Natural killer (NK) cells have the capability of lysing targets that have down-regulated the expression of HLA class I molecules. Herpes simplex virus (HSV) infection results in a profound reduction of HLA class I molecules on the surface of infected cells. For this reason, NK cell populations killefficiently HSV-infected cells. The recent availability of a panel of monoclonal antibodies directed to NK receptors for HLA class I (CD158a, CD158b,anti-p70, anti-p140, and CD94) allowed an accurate dissection of the NK cell subpopulations. Using this approach, the relationship between the expression of NK cell receptors and the capability of lysing HSV-infected cell targets was analyzed at the clonal level. NK cell clones were derived from healthy donors, and cytolytic properties were assayed against HSV-infected autologous fibroblasts. NK cell clones, classified according to the expression of natural killer-cell receptors on their surface, displayed a great heterogeneity of cytolytic properties against HSV-infected cells. Nevertheless,a more accurate functional analysis demonstrated not only that HSV infection downregulated the expression of HLA-A and HLA-B and did not modify the expression of HLA-C, but also that NK cell clones expressing the "activating" form of the anti HLA-C NK cell receptor were more cytolytic than other clones. This finding suggests that two different and clonally distributed mechanisms of NK cell activation may be employed by NK cells to kill HSV-infected autologous target cells. J. Med. Virol, 62:354-363, 2000. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:33:18