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Titolo:
Effect of argatroban on trinitrobenzene sulfonic acid-induced colitis
Autore:
Onomura, M; Tsukada, H; Fukuda, K; Kodama, M; Nakamura, H; Hosokawa, M; Ohya, M; Seino, Y;
Indirizzi:
Kyoto Univ, Fac Med, Dept Metab & Clin Nutr, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Clin Nutr, Sakyo Ku, Kyoto 6068507, Japan
Titolo Testata:
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
fascicolo: 8, volume: 15, anno: 2000,
pagine: 931 - 938
SICI:
0815-9319(200008)15:8<931:EOAOTS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNTHETIC THROMBIN INHIBITOR; INFLAMMATORY BOWEL-DISEASE; ULCERATIVE-COLITIS; CROHNS-DISEASE; HEPARIN; RAT; MODEL; COAGULATION;
Keywords:
argatroban; trinitrobenzene sulphonic acid-induced colitis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Onomura, M Kyoto Univ, Fac Med, Dept Metab & Clin Nutr, Sakyo Ku, 54 Shogoin Kawarachou, Kyoto 6068507, Japan Kyoto Univ 54 Shogoin Kawarachou KyotoJapan 6068507 07, Japan
Citazione:
M. Onomura et al., "Effect of argatroban on trinitrobenzene sulfonic acid-induced colitis", J GASTR HEP, 15(8), 2000, pp. 931-938

Abstract

Background: Recent studies have suggested that heparin is effective for treatment of inflammatory bowel disease (IBD) and its various effects (in addition to the anticoagulant effect). We evaluated the effects of argatroban as an antithrombin drug on trinitrobenzene sulfonic acid (TNB)-induced colitis, an established model of IBD. Methods: Rats were randomly assigned to four groups in which mini-osmotic pumps containing saline (TNB-S), argatroban (TNB-A), or 100 U/kg heparin (TNB-H) were intraperitoneally implanted. Three days after the pumps were implanted,TNB was infused via the anus, and colitis was induced. After 5 days,prothrombin time (PT), activated partial prothrombin time (APTT), antithrombin III (AT-III), platelet, fibrinogen, colonic wet weight, macroscopic damage score, histological score, mucosal myeloperoxidase activity and mucosal leukotrien B-4 (LTB4) levels were compared among the four groups. Results: The APTT was prolonged in the heparin treatment group but only slightly prolonged in the argatroban treatment group. The platelet count and the fibrinogen level were higher in the TNB-S group than in the healthy control group and the AT-III level was slightly lower in the TNB-S group than in the healthy control group and lower still in the TNB-H group. Conclusions: The colonic wet weight was similar among the four groups while the macroscopic damage score, histological score, mucosal myeloperoxidaseactivity and the mucosal LTB4 level were significantly decreased in the TNB-A and TNB-H groups. Argatroban, as well as heparin may be effective for treatment of TNB-induced colitis. (C) 2000 Blackwell Science Asia Pty Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:34:36