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Titolo:
Germinal center Initiation, variable gene region hypermutation, and mutantB cell selection without detectable immune complexes on follicular dendritic cells
Autore:
Hannum, LG; Haberman, AM; Anderson, SM; Shlomchik, MJ;
Indirizzi:
Yale Univ, Sch Med, Dept Lab Med, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 d, Dept Lab Med, New Haven, CT 06520 USA Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 Immunobiol Sect, New Haven, CT 06520 USA
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 7, volume: 192, anno: 2000,
pagine: 931 - 942
SICI:
0022-1007(20001002)192:7<931:GCIVGR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIGEN-DRIVEN SELECTION; INFLUENZA-VIRUS HEMAGGLUTININ; T-DEPENDENT ANTIGEN; DEFICIENT MICE; COMPLEMENT RECEPTOR-1; SECONDARY RESPONSES; AFFINITY MATURATION; ANTIBODY-RESPONSE; LYMPHOTOXIN-ALPHA; IN-SITU;
Keywords:
B lymphocyte; transgenic mouse; surface immunoglobulin; lambda light chain; immunological memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Shlomchik, MJ Yale Univ, Sch Med, Dept Lab Med, POB 208035,330 Cedar St, New Haven, CT 06520 USA Yale Univ POB 208035,330 Cedar St New Haven CT USA 06520 USA
Citazione:
L.G. Hannum et al., "Germinal center Initiation, variable gene region hypermutation, and mutantB cell selection without detectable immune complexes on follicular dendritic cells", J EXP MED, 192(7), 2000, pp. 931-942

Abstract

Serum antibody (Ab) can Flay several roles during B cell immune responses. Among these is to promote the deposition of immune complexes (ICs) on follicular dendritic cells (FDCs). ICs on FDCs are generally thought to be critical for normal germinal center (GC) formation and the development and selection of memory B cells. However, it has been very difficult to test these ideas. To determine directly whether FDC-bound complexes do indeed functionin these roles, we have developed a transgenic (Tg) mouse in which all B lymphocytes produce only the membrane-bound form of immunoglobulin M. ImmuneTg mice have 10,000-fold less specific Ab than wild-type mice and lack detectable ICs on FDCs. Nonetheless, primary immune responses and the GC reaction in these mice are robust, suggesting that ICs on FDCs do not play critical roles in immune response initiation and GC formation. Moreover, as indicated by the presence and pattern of somatic mutations, memory cell formation and selection appear normal in these IC-deficient GCs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:53:05