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Titolo:
Adenoviruses as vectors for delivering vaccines to mucosal surfaces
Autore:
Babiuk, LA; Tikoo, SK;
Indirizzi:
Univ Saskatchewan, Vet Infect Dis Org, Saskatoon, SK S7N 5E3, Canada Univ Saskatchewan Saskatoon SK Canada S7N 5E3 skatoon, SK S7N 5E3, Canada
Titolo Testata:
JOURNAL OF BIOTECHNOLOGY
fascicolo: 1-2, volume: 83, anno: 2000,
pagine: 105 - 113
SICI:
0168-1656(20000929)83:1-2<105:AAVFDV>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
BOVINE HERPESVIRUS TYPE-1; TUMOR-NECROSIS-FACTOR; IMMUNE-RESPONSES; EXPRESSION VECTOR; GLYCOPROTEIN GD; FULL-LENGTH; VIRUS; GENE; IMMUNIZATION; RECOMBINANTS;
Keywords:
virus; antibody; immunization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Babiuk, LA Univ Saskatchewan, Vet Infect Dis Org, 120 Vet Rd, Saskatoon, SK S7N 5E3, Canada Univ Saskatchewan 120 Vet Rd Saskatoon SK Canada S7N 5E3 Canada
Citazione:
L.A. Babiuk e S.K. Tikoo, "Adenoviruses as vectors for delivering vaccines to mucosal surfaces", J BIOTECH, 83(1-2), 2000, pp. 105-113

Abstract

Immunization of mucosal surfaces has become an attractive route of vaccinedelivery because of its ability to induce mucosal immunity. Although various methods of inducing mucosal immunity are being developed, our laboratoryhas focused on developing adenoviruses as replication-competent and replication-incompetent vectors. The present report will summarize our progress in sequencing the entire bovine adenovirus-3 genome and identifying regions which can be deleted and subsequently used as insertion sites for foreign genes in developing recombinant viral vaccines. Using these recombinant viruses, we demonstrated the 'proof-of-principle' in developing mucosal immunity and, more importantly, inducing protection against bovine herpes virus ina natural host-cattle. Finally, we demonstrated that immunity and protection occurred even in animals that had pre-existing antibodies to the vector. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:55:55