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Titolo:
Transport of mitochondria during axonogenesis
Autore:
Dedov, VN; Dedova, IV; Armati, PJ;
Indirizzi:
Univ Sydney, Sch Biol Sci, Dept Pharm, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 Pharm, Sydney, NSW 2006, Australia Univ Sydney, Sch Biol Sci, Dept Anat, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 t Anat, Sydney, NSW 2006, Australia Univ Sydney, Sch Biol Sci, Neurosci Unit, Sydney, NSW 2006, Australia UnivSydney Sydney NSW Australia 2006 i Unit, Sydney, NSW 2006, Australia
Titolo Testata:
IUBMB LIFE
fascicolo: 6, volume: 49, anno: 2000,
pagine: 549 - 552
SICI:
1521-6543(200006)49:6<549:TOMDA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-CONE; NEURONS; MECHANISMS; CALCIUM; MICROTUBULES; EXTENSION; JC-1;
Keywords:
axonogenesis; dorsal root ganglion neurons; JC-1; mitochondria; mitochondrial membrane potential; neuronal regeneration; plasma membrane;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Dedov, VN Univ Sydney, Sch Biol Sci, Dept Pharm, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 dney, NSW 2006, Australia
Citazione:
V.N. Dedov et al., "Transport of mitochondria during axonogenesis", IUBMB LIFE, 49(6), 2000, pp. 549-552

Abstract

The cellular mechanisms involved in axonogenesis are still unclear, In thepresent work we found that formation of neurites in cultured neonatal dorsal root ganglion neurons co-incided with the redistribution of highly charged mitochondria, Radially distributed in subplasmalemmal space 3 h after plating, highly charged mitochondria formed clusters in the hillocks of predominant neurites during the nest 24-48 h and then redistributed into the axons, These results provide evidence that accumulation of a critical mass of charged mitochondria at the site of the future axonal hillock may representthe slow initiation stage of axonogenesis, followed by a fast growth phase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 07:32:45