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Titolo:
Elevation of vitreous leptin in diabetic retinopathy and retinal detachment
Autore:
Gariano, RF; Nath, AK; DAmico, DJ; Lee, T; Sierra-Honigmann, MR;
Indirizzi:
Yale Univ, Sch Med, Dept Ophthalmol & Visual Sci, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 ol & Visual Sci, New Haven, CT 06520 USA Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 ed, Dept Pathol, New Haven, CT 06520 USA Harvard Univ, Sch Med, Dept Ophthalmol, Boston, MA USA Harvard Univ Boston MA USA niv, Sch Med, Dept Ophthalmol, Boston, MA USA
Titolo Testata:
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
fascicolo: 11, volume: 41, anno: 2000,
pagine: 3576 - 3581
SICI:
0146-0404(200010)41:11<3576:EOVLID>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; BODY-WEIGHT; INSULIN CONCENTRATIONS; SERUM LEPTIN; OBESE GENE; RAT-BRAIN; MICE; EXPRESSION; RECEPTOR; MELLITUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Gariano, RF Yale Univ, Ctr Eye, 330 Cedar St, New Haven, CT 06520 USA YaleUniv 330 Cedar St New Haven CT USA 06520 en, CT 06520 USA
Citazione:
R.F. Gariano et al., "Elevation of vitreous leptin in diabetic retinopathy and retinal detachment", INV OPHTH V, 41(11), 2000, pp. 3576-3581

Abstract

PURPOSE. Leptin is a cytokine that regulates energy metabolism and is linked to diabetes mellitus through its metabolic actions. Leptin is angiogenicand promotes wound healing, and therefore this investigation was conductedto determine whether leptin is associated with neovascular and fibrotic complications of diabetes and other retinopathies. METHODS. Serum and vitreous samples were collected from patients classified by the presence and type of diabetic retinopathy or other ocular diseases. Leptin was measured in serum and vitreous by radioimmunoassay, and leptinand Leptin receptor were localized in epiretinal membranes immunohistochemically. RESULTS. Leptin levels in serum and vitreous were higher in patients with diabetes than in those without, and vitreous leptin concentrations were especially elevated in patients with proliferative diabetic retinopathy or retinal detachment. Leptin and leptin receptor were detected in fibrovascular epiretinal membrane of patients with diabetes. CONCLUSIONS. Leptin in human vitreous is elevated in proliferative diabetic retinopathy and retinal detachment and is present in fibrovascular epiretinal tissue. These data suggest an involvement of leptin in retinal disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:17:14