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Titolo:
Association of dopamine D2 receptor polymorphisms Ser311Cys and TaqIA withobesity or type 2 diabetes mellitus in Pima Indians
Autore:
Jenkinson, CP; Hanson, R; Cray, K; Wiedrich, C; Knowler, WC; Bogardus, C; Baier, L;
Indirizzi:
NIDDKD, Phoenix Epidemiol & Clin Res Branch, NIH, Phoenix, AZ USA NIDDKD Phoenix AZ USA Epidemiol & Clin Res Branch, NIH, Phoenix, AZ USA
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 10, volume: 24, anno: 2000,
pagine: 1233 - 1238
SICI:
0307-0565(200010)24:10<1233:AODDRP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE TRAIT LOCI; BODY-MASS INDEX; STRIATAL DOPAMINE; GENETIC-LINKAGE; CONSCIOUS RATS; ADMIXTURE; VARIANTS; HAMSTERS; RELEASE; DRD2;
Keywords:
DRD2; dopamine; obesity; diabetes; association; single nucleotide polymorphisms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Jenkinson, CP Univ Texas, Hlth Sci Ctr, Mail Stop 7886,7703 Floyd Curl Dr,San Antonio, TX 78229 USA Univ Texas Mail Stop 7886,7703 Floyd Curl Dr SanAntonio TX USA 78229
Citazione:
C.P. Jenkinson et al., "Association of dopamine D2 receptor polymorphisms Ser311Cys and TaqIA withobesity or type 2 diabetes mellitus in Pima Indians", INT J OBES, 24(10), 2000, pp. 1233-1238

Abstract

OBJECTIVES: To investigate whether (a) variants within the dopamine D2 receptor gene (DRD2) are associated with obesity and type 2 diabetes in Pima Indians, and (b) whether variation in this gene could be responsible for previously observed linkage to these phenotypes, at chromosome location 11q23 - 24, in this population. DESIGN: Two single nucleotide polymorphisms (SNPs), Ser311Cys and TaqIA, within the DRD2 gene were genotyped by allelic discrimination PCR in subjects who had provided evidence of linkage to diabetes and obesity in an autosome-wide scan. SUBJECTS: A total of 1187 subjects were genotyped, including 947 full heritage Pima Indians (80%). Descriptive statistics for all subjects analyzed, for whom clinical data were available, were (mean+/-s.d.): age at time of last exam=41+/-15 y; birth year=1950+/-14; age-sex-adjusted body mass index (BMI; adjusted to a mean age of 35 y) = 36 +/- 8 kg/m(2); male = 44%; diabetic = 57%. For full heritage Pimas only: age = 43 +/- 15 y; birth year = 1948 +/- 14; sex-age-adjusted BMI = 36 +/- 8 kg/m(2); male = 43%; diabetic = 59%. RESULTS: Neither polymorphism was significantly associated with diabetes in full heritage Pimas. Individuals with a 'CG' genotype at the Ser311Cys SNP had a higher BMI than those with a 'CC' genotype (36.7 vs 35.5 kg/m(2), P= 0.04). Linkage analysis of BMI, adjusted for either polymorphism, resulted in LOD scores that were similar to those obtained without adjustment. CONCLUSION: Heterozygotes at the Ser311Cys DRD2 polymorphism had a slightly higher BMI than homozygotes, however neither the Ser311Cys nor the TaqIA polymorphism accounted for the linkage with BMI on chromosome 11 in Pima Indians.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:24:23