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Titolo:
Glial somatostatin-14 expression in the rat pituitary intermediate lobe: apossible neurotrophic function during development?
Autore:
Chronwall, BM; Sands, SA; Cummings, KC; Schwartz, JP;
Indirizzi:
Univ Missouri, Sch Biol Sci, Kansas City, MO 64110 USA Univ Missouri Kansas City MO USA 64110 iol Sci, Kansas City, MO 64110 USA NINDS, Neurotroph Factors Sect, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 urotroph Factors Sect, Bethesda, MD 20892 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
fascicolo: 7, volume: 18, anno: 2000,
pagine: 685 - 692
SICI:
0736-5748(200011)18:7<685:GSEITR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSIENT EXPRESSION; GFAP EXPRESSION; MESSENGER-RNA; INSITU HYBRIDIZATION; NEURITE OUTGROWTH; GENE-EXPRESSION; NEONATAL RAT; HYPOTHALAMUS; ONTOGENY; SYSTEM;
Keywords:
glia-derived neurotrophic factor; axonal guidance; immunohistochemistry; RT-PCR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Chronwall, BM Univ Missouri, Sch Biol Sci, 5100 Rockhill Rd, Kansas City, MO 64110 USA Univ Missouri 5100 Rockhill Rd Kansas City MO USA 64110 USA
Citazione:
B.M. Chronwall et al., "Glial somatostatin-14 expression in the rat pituitary intermediate lobe: apossible neurotrophic function during development?", INT J DEV N, 18(7), 2000, pp. 685-692

Abstract

Somatostatin-14 was first detected on gestational day 17 in radially-oriented, bipolar cells spanning the width of the intermediate lobe of the rat pituitary. Cells were prominent, and constituted approximately 50% of the lobe area. The presence of vimentin, the cellular shape, and the localizationidentified these cells as glia. At postnatal day 6, somatostatin-14 and vimentin staining appeared in stellate-shaped cells. This is in agreement with the change from bipolar to stellate shape these glia undergo after the onset of innervation ([13] Gary et al. Int. J. Devl. Neurosci. 13, 555-565, 1995). Glia were more abundant, relative to melanotropes, throughout embryonic and early postnatal development compared to adulthood. Reverse transcription-polymerase chain reaction data showed a high level of prosomatostatin mRNA in the intermediate lobe: compared to the anterior and neural lobes from postnatal day 2 animals, and a significant drop in intermediate lobe content in the adult. The correlation between the number of glia and high expression of somatostatin in neonatal relative to adult tissue, together withthe close apposition of incoming axons to the abundant, radially oriented glia during innervation of the lobe, support a neurotrophic function of glia-derived somatostatin. Published by Elsevier Science Ltd on behalf of ISDN.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 00:24:52