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Titolo:
Glial cell line-derived neurotrophic factor (GDNF) as a defensive moleculefor neurodegenerative disease: a tribute to the studies of Antonia Vernadakis on neuronal-glial interactions
Autore:
Bohn, MC; Kozlowski, DA; Connor, B;
Indirizzi:
Northwestern Univ, Childrens Mem Hosp, Sch Med, Dept Pediat,Childrens Mem Inst Educ & Res, Chicago, IL 60613 USA Northwestern Univ Chicago IL USA 60613 Educ & Res, Chicago, IL 60613 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
fascicolo: 7, volume: 18, anno: 2000,
pagine: 679 - 684
SICI:
0736-5748(200011)18:7<679:GCLNF(>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NIGRAL DOPAMINERGIC-NEURONS; PARKINSONS-DISEASE; NERVOUS-SYSTEM; RAT MODEL; IN-VIVO; 6-HYDROXYDOPAMINE LESION; INTRASTRIATAL INJECTION; MESENCEPHALIC GLIA; FOS EXPRESSION; GENE-THERAPY;
Keywords:
gene therapy; dopaminergic neurons; Parkinson's disease; amyotrophic lateral sclerosis; adenovirus; motoneurons; tyrosine hydroxylase;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Bohn, MC Northwestern Univ, Childrens Mem Hosp, Sch Med, Dept Pediat,Childrens Mem Inst Educ & Res, 2300 Childrens Plaza,Box 209, Chicago, IL 60613 USA Northwestern Univ 2300 Childrens Plaza,Box 209 Chicago IL USA 60613
Citazione:
M.C. Bohn et al., "Glial cell line-derived neurotrophic factor (GDNF) as a defensive moleculefor neurodegenerative disease: a tribute to the studies of Antonia Vernadakis on neuronal-glial interactions", INT J DEV N, 18(7), 2000, pp. 679-684

Abstract

Research stemming from interests in neuronal-glial interactions has led tothe identification of a number of novel trophic factors. such as the dopaminergic neurotrophic factor glial cell line-derived neurotrophic factor (GDNF). Delivery of the GDNF gene to rat models of Parkinson's disease suggests a potential clinical use of GDNF gene therapy for humans with this disease. This review article briefly summarizes the history of GDNF and the effects of GDNF gene delivery prior to or after a lesion of the rat nigrostriatal system. (C) 2000 ISDN. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 00:07:52