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Titolo:
CYTOMEGALOVIRUS (CMV) CULTURE RESULTS, DRUG-RESISTANCE, AND CLINICAL OUTCOME IN PATIENTS WITH AIDS AND CMV RETINITIS TREATED WITH FOSCARNETOR GANCICLOVIR
Autore:
LEWIS RA; CLOGSTON P; FAINSTEIN V; GROSS R; SAMO T; TUTTLE C; JABS DA; APUZZO L; BARTLETT J; COLESON L; DUNN JP; ELDRED L; FEINBERG J; FLYNN T; KING R; LESLIE J; BARRON B; GREENSPAN D; LECOUNT C; PEYMAN G; FRANKLIN R; HEINEMANN MH; POLSKY B; SQUIRES K; WISECAMPBELL S; FRIEDMAN AH; CHEUNG AW; JUSTIN N; TEICH S; SACKS H; SEVERIN C; FRIEDBERG DN; ADDESSI A; DIETERICH D; FROST K; WEINBERG D; JAMPOL L; MURPHY R; NAUGHTON K; HENDERLY D; HOLLAND GN; CHAFEY S; FALL H; HARDY WD; KIMBRELL C; MACARTHURCHANG L; FREEMAN WR; MEIXNERT L; PETERSON TJ; QUICENO JI; RICKMAN L; SIMANELLO MA; SPECTOR S; ODONNELL J; HOFFMAN J; IRVINE A; JACOBSON M; LARSON J; SEIFF S; WANNER M; DAVIS J; CHUANG E; ESPINAL M; MENDEZ P; VANDENBROUCKE R; DODGE JM; STEVENS M; BROWNBELLAMY J; KLEMM AC; MARKOWITZ JA; WEBB R; MEINERT CL; AMENDLIBERCCI D; COLESONSCHREUR L; COLLINS KL; COLLISON BJ; DODGE J; DONITHAN M; FINK N; KAPLANGILPIN AM; GERCZAK C; HOLBROOK JT; ISAACSON MR; LANE MF; LEVINE CR; MARTIN BK; MIN YI; OWENS RM; NOWAKOWSKI DJ; SAAH A; TONASCIA J; VANNATTA ML; DAVIS MD; AGRESSEGAL M; ARMSTRONG J; BROTHERS R; FREITAG G; HUBBARD L; HURLBURT D; KASTORFF L; MAGLI Y; MINER K; THOMAS S; VANDERHOOFYOUNG M; DREW WL; MINOR R; STEWART G; HUGHES R; WELCH L; MOWERY R; ELLENBERG S; KORVICK J; SATTLER F; BROWN BW; CONWAY B; GRIZZLE J; NUSSENBLATT R; PHAIR J; SMITH H; WHITLEY R;
Indirizzi:
SOCA,CHAIRMANS OFF,550 N BROADWAY,SUITE 700 BALTIMORE MD 21205 BAYLOR COLL MED,CULLEN EYE INST HOUSTON TX 77030 JOHNS HOPKINS UNIV,SCH MED BALTIMORE MD 00000 LOUISIANA STATE UNIV,MED CTR NEW ORLEANS LA 00000 MEM SLOAN KETTERING CANC CTR NEW YORK NY 10021 CORNELL UNIV,MED CTR,NEW YORK HOSP NEW YORK NY 10021 MT SINAI SCH MED NEW YORK NY 00000 NYU,MED CTR NEW YORK NY 10016 NORTHWESTERN UNIV CHICAGO IL 60611 UNIV CALIF LOS ANGELES LOS ANGELES CA 00000 UNIV CALIF SAN DIEGO SAN DIEGO CA 92103 UNIV CALIF SAN FRANCISCO SAN FRANCISCO CA 94143 UNIV MIAMI,SCH MED MIAMI FL 00000 UNIV MIAMI,SCH MED MIAMI FL 00000 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,COORDINATING CTR BALTIMORE MD 00000 JOHNS HOPKINS UNIV,SCH MED,CHAIRMANS OFF BALTIMORE MD 00000 UNIV WISCONSIN,FUNDUS PHOTOGRAPH READING CTR MADISON WI 00000 UNIV CALIF SAN FRANCISCO,ANTIVIRAL SUSCEPTIBIL TESTING CTR SAN FRANCISCO CA 94143 ERC BIOSERV CORP,DRUG DISTRIBUT CTR ROCKVILLE MD 00000 NEI BETHESDA MD 20892 NIAID BETHESDA MD 20892
Titolo Testata:
The Journal of infectious diseases
fascicolo: 1, volume: 176, anno: 1997,
pagine: 50 - 58
SICI:
0022-1899(1997)176:1<50:C(CRDA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRUS RETINITIS; INFECTION; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Lewis et al., "CYTOMEGALOVIRUS (CMV) CULTURE RESULTS, DRUG-RESISTANCE, AND CLINICAL OUTCOME IN PATIENTS WITH AIDS AND CMV RETINITIS TREATED WITH FOSCARNETOR GANCICLOVIR", The Journal of infectious diseases, 176(1), 1997, pp. 50-58

Abstract

The objectives of the study were to examine the clinical significanceof cytomegalovirus (CMV) culture results and drug susceptibilities inCMV isolates from patients with AIDS-related CMV retinitis, Blood andurine for CMV culture were obtained from 207 patients with newly diagnosed CMV retinitis who were enrolled in a randomized trial comparing foscarnet and ganciclovir. Culture-positive rates at baseline were 45%and 71% for blood and urine, respectively. Rates decreased 3- to 10-fold after initiation of either treatment. Mortality was related to both positive baseline blood and urine cultures; adjusted relative risks were 1.97 and 2.03, respectively, Positive blood cultures at baseline were associated with more rapid retinitis progression. Drug-resistant CMV was found, over comparable follow-up periods on assigned treatment, in 4 of 8 ganciclovir-assigned patients with persistent viremia and 0 of 5 foscarnet-assigned patients with persistent viremia, Results ofvirologic assays of blood appear to be associated with clinical outcome of CMV retinitis.

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Documento generato il 14/08/20 alle ore 03:18:07