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Titolo:
THE SYNAPTIC ACTIVATION OF KAINATE RECEPTORS
Autore:
VIGNES M; COLLINGRIDGE GL;
Indirizzi:
UNIV BRISTOL,SCH MED SCI,DEPT ANAT,UNIV WALK BRISTOL BS8 1TD AVON ENGLAND UNIV BRISTOL,SCH MED SCI,DEPT ANAT BRISTOL BS8 1TD AVON ENGLAND
Titolo Testata:
Nature
fascicolo: 6638, volume: 388, anno: 1997,
pagine: 179 - 182
SICI:
0028-0836(1997)388:6638<179:TSAOKR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; GLUTAMATE RECEPTORS; HIPPOCAMPAL-NEURONS; NERVOUS-SYSTEM; EXPRESSION; SUBUNIT; CLONING; CELLS; AMPA; CYCLOTHIAZIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
M. Vignes e G.L. Collingridge, "THE SYNAPTIC ACTIVATION OF KAINATE RECEPTORS", Nature, 388(6638), 1997, pp. 179-182

Abstract

L-Glutamate, the principal excitatory neurotransmitter in the vertebrate central nervous system, acts on three classes of ionotropic glutamate receptors, named after the agonists AMPA, NMDA and kainate(1). AMPA receptors are known to mediate fast synaptic responses and NMDA receptors to mediate slow synaptic responses at most excitatory synapses in the brain(2). Kainate receptors are formed from a separate set of genes (GluR5-7, KA-1 and KA-2) and are widely distributed throughout thebrain(3-8). They are implicated in epileptogenesis and cell death(9). However, the physiological functions of kainate receptors are not known. The development of 2,3-benzodiazepine antagonists that are selective for AMPA receptors(10) enables kainate receptors to be specificallyactivated by exogenous ligands, such as kainate(11-16). Here we demonstrate that high-frequency stimulation of messy fibres in rat hippocampal slices, in the presence of the highly selective AMPA receptor antagonist GYKI 53655 (refs 13-15) plus NMDA- and GABA-receptor antagonists, activates an inward current in CA3 neurons that has a pharmacology typical of kainate receptors. The finding that kainate receptors can be activated synaptically adds to the diversity of information transferat glutamatergic synapses.

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Documento generato il 06/07/20 alle ore 04:46:41