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Titolo:
The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines
Autore:
Li, BQ; Fu, T; Gong, WH; Dunlop, N; Kung, HF; Yan, YD; Kang, J; Wang, JM;
Indirizzi:
NCI, Frederick Canc Res & Dev Ctr, Intramural Res Support Program, SAIC Frederick, Frederick, MD 21702 USA NCI Frederick MD USA 21702 ogram, SAIC Frederick, Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Mol Immunoregulat Lab, Frederick, MD 21702 USA NCI Frederick MD USA 21702 Mol Immunoregulat Lab, Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Lab Biochem Physiol, Div Basic Sci, Frederick, MD 21702 USA NCI Frederick MD USA 21702 hysiol, Div Basic Sci, Frederick, MD 21702 USA Shenyang AF Hosp, Sheng Yang, Liaoning, Peoples R China Shenyang AF Hosp Sheng Yang Liaoning Peoples R China ng, Peoples R China New York Med Coll, Dept Cell Biol & Anat, Valhalla, NY 10595 USA New York Med Coll Valhalla NY USA 10595 ol & Anat, Valhalla, NY 10595 USA
Titolo Testata:
IMMUNOPHARMACOLOGY
fascicolo: 3, volume: 49, anno: 2000,
pagine: 295 - 306
SICI:
0162-3109(200009)49:3<295:TFBEAA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE LEUKOCYTE RECEPTORS; PROTEIN-3 MCP3 INTERACTS; HERBAL MEDICINE; CELL-LINES; IDENTIFICATION; INHIBITION; GROWTH; CCR5; INTERLEUKIN-8; ANTAGONISTS;
Keywords:
flavonoid; baicalin; chemokines; receptors; anti-inflammation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Li, BQ NCI, Frederick Canc Res & Dev Ctr, Intramural Res Support Program, SAIC Frederick, Bldg 560,Room 31-40, Frederick, MD 21702 USA NCI Bldg 560,Room 31-40 Frederick MD USA 21702 derick, MD 21702 USA
Citazione:
B.Q. Li et al., "The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines", IMMUNOPHARM, 49(3), 2000, pp. 295-306

Abstract

Baicalin (BA) is a flavonoid compound purified from the medicinal plant Scutellaria baicalensis Georgi acid has been reported to possess anti-inflammatory and anti-viral activities. In order to elucidate the mechanism(s) of action of BA, we tested whether BA could interfere with chemokines or chemokine receptors, which are critical mediators of inflammation and infection. We observed that BA inhibited the binding of a number of chemokines to human leukocytes or cells transfected to express specific chemokine receptors. This was associated with a reduced capacity of the chemokines to induce cell migration. Go-injection of BA with CXC chemokine interleukin-8 (IL-8) into rat skin significantly inhibited IL-8 elicited neutrophil infiltration. BA did not directly compete with chemokines for binding to receptors, but rather acted through its selective binding to chemokine ligands. This conclusion was supported by the fact that BA cross-linked to oxime resin bound chemokines of the CXC (stromal cell-derived factor (SDF)-1 alpha, IL-8), CC (macrophage inflammatory protein (MIP)-1 beta, monocyte chemotactic protein (MCP)-2), and C (lymphotactin (Ltn)) subfamilies, BA did not interact with CX3C chemokine fractalkine/neurotactin or other cytokines, such as TNF-alpha and IFN-gamma, indicating that its action is selective. These results suggest that one possible anti-inflammatory mechanism of BA is to bind a variety of chemokines and limit their biological function. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 15:26:37