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Titolo:
Recent developments in neuronal nicotinic acetylcholine receptor antagonists
Autore:
Dwoskin, LP; Xu, R; Ayers, JT; Crooks, PA;
Indirizzi:
Univ Kentucky, Coll Pharm, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 Coll Pharm, Lexington, KY 40536 USA
Titolo Testata:
EXPERT OPINION ON THERAPEUTIC PATENTS
fascicolo: 10, volume: 10, anno: 2000,
pagine: 1561 - 1581
SICI:
1354-3776(200010)10:10<1561:RDINNA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; SUBUNIT MESSENGER-RNA; H-3 DOPAMINE RELEASE; ALPHA-BUNGAROTOXIN RECEPTORS; BOVINE CHROMAFFIN CELLS; CENTRAL-NERVOUS-SYSTEM; RAT SUBSTANTIA-NIGRA; LIGAND-BINDING SITES; MOUSE-BRAIN; PHARMACOLOGICAL PROPERTIES;
Keywords:
acetylcholine receptor; Alzheimer's disease; anabaseine; anabasine; conotoxin; dihydro-beta-erythroidine; drug abuse; GTS-21; lobeline; mecamylamine; NDNI; neuronal nicotinic cholinergic channel blockers; nicotine; NONI; Parkinson's disease;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
152
Recensione:
Indirizzi per estratti:
Indirizzo: Dwoskin, LP Univ Kentucky, Coll Pharm, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 Lexington, KY 40536 USA
Citazione:
L.P. Dwoskin et al., "Recent developments in neuronal nicotinic acetylcholine receptor antagonists", EXPERT OP T, 10(10), 2000, pp. 1561-1581

Abstract

Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a superfamily of ligand-gated ion channel receptors and are distributed extensively throughout the central and peripheral nervous systems. The structural and functional diversity of these receptors has stimulated interest in the development of subtype-selective agonists, as a result of a greater understanding of the role of these receptors in neuropathology and disease, including Alzheimer's and Parkinson's disease, Tourette's syndrome, drug addiction and pain. Surprisingly, much less attention has been focused on the development of subtype-selective antagonists, which may also be useful as therapeutic agents. This article reviews the published patent literature on neuronal nicotinic receptor antagonists, with particular attention to receptor subtype selectivity of novel compounds that have been recently disclosed in the patent literature.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:40:58