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Titolo:
Mechanisms of renal calcium transport
Autore:
Friedman, PA;
Indirizzi:
Univ Pittsburgh, Sch Med, Dept Pharmacol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 armacol, Pittsburgh, PA 15261 USA Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 ept Med, Pittsburgh, PA 15261 USA
Titolo Testata:
EXPERIMENTAL NEPHROLOGY
fascicolo: 6, volume: 8, anno: 2000,
pagine: 343 - 350
SICI:
1018-7782(200011/12)8:6<343:MORCT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISTAL CONVOLUTED TUBULE; NONSELECTIVE CATION CHANNEL; PARATHYROID-HORMONE; BARTTERS-SYNDROME; HYPOKALEMIC ALKALOSIS; FUNCTIONAL EXPRESSION; NA+-CA-2+ EXCHANGER; GITELMANS-SYNDROME; MOLECULAR-CLONING; EPITHELIAL-CELLS;
Keywords:
calcium excretion; nephron segments; calcium channels; ion channels; parathyroid hormone; diuretics; Gitelman's syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Friedman, PA Univ Pittsburgh, Sch Med, Dept Pharmacol, E-1347 Biomed Sci Tower, Pittsburgh, PA 15261 USA Univ Pittsburgh E-1347 Biomed Sci Tower Pittsburgh PA USA 15261
Citazione:
P.A. Friedman, "Mechanisms of renal calcium transport", EXP NEPHROL, 8(6), 2000, pp. 343-350

Abstract

The kidneys play a key role in the integrated regulation of calcium homeostasis. Calcium absorption takes place throughout the nephron, Proximal tubules, thick ascending limbs of Henle's loop, and distal tubules are the major sites of calcium absorption. The mechanisms of absorption vary significantly from one seg ment to another, as does the extent of hormonal regulation, At one extreme is the considerable reabsorption by proximal tubules that proceeds primarily, if not entirely, by a paracellular pathway that is not regulated by hormones or drugs. In thick ascending limbs, calcium absorption occurs through a combination of transcellular and paracellular routes. The active, transcellular component is regulated by parathyroid hormone (PTH)and calcitonin, whereas the passive, paracellular route is governed by theextent of concomitant sodium absorption. At the other extreme is the distal tubule, where calcium absorption is entirely transcellular and is regulated by PTH, 1,25(OH)(2)vitamin D-3, calcitonin, and by calcium-sparing drugssuch as thiazide-type diuretics, The present review focuses on recent insights into the mechanisms of transcellular calcium movement and highlights the discovery of an epithelial calcium channel, ECaC, that may mediate calcium entry in distal tubules, Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 22:32:37