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Titolo:
The effects of allopurinol in hepatic ischemia and reperfusion: Experimental study in rats
Autore:
Rhoden, E; Pereira-Lima, L; Lucas, M; Mauri, M; Rhoden, C; Pereira-Lima, JC; Zettler, C; Petteffi, L; Bello-Klein, A;
Indirizzi:
Clin Hosp Porto Alegre, Course Postgrad Med Clin, Porto Alegre, RS, BrazilClin Hosp Porto Alegre Porto Alegre RS Brazil , Porto Alegre, RS, Brazil Santa Casa Univ Hosp, Porto Alegre Sch Med Sci, Dept Pharmacol, Porto Alegre, RS, Brazil Santa Casa Univ Hosp Porto Alegre RS Brazil ol, Porto Alegre, RS, Brazil Santa Casa Univ Hosp, Porto Alegre Sch Med Sci, Dept Gastroenterol, Porto Alegre, RS, Brazil Santa Casa Univ Hosp Porto Alegre RS Brazil ol, Porto Alegre, RS, Brazil Santa Casa Univ Hosp, Porto Alegre Sch Med Sci, Dept Pathol, Porto Alegre,RS, Brazil Santa Casa Univ Hosp Porto Alegre RS Brazil hol, Porto Alegre,RS, Brazil Univ Fed Rio Grande Sul, Dept Physiol, Porto Alegre, RS, Brazil Univ Fed Rio Grande Sul Porto Alegre RS Brazil Porto Alegre, RS, Brazil
Titolo Testata:
EUROPEAN SURGICAL RESEARCH
fascicolo: 4, volume: 32, anno: 2000,
pagine: 215 - 222
SICI:
0014-312X(200007/08)32:4<215:TEOAIH>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXYGEN-FREE-RADICALS; LIVER-CELL INJURY; XANTHINE-OXIDASE; LIPID-PEROXIDATION; KUPFFER CELLS; TISSUE-INJURY;
Keywords:
ischemia, hepatic; allopurinol; oxygen free radicals; lipid peroxidation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Pereira-Lima, JC Rua Comendador Rheingantz 910,Apto 801, BR-90450020 PortoAlegre, RS, Brazil Rua Comendador Rheingantz 910,Apto 801 Porto Alegre RSBrazil BR-90450020 BC
Citazione:
E. Rhoden et al., "The effects of allopurinol in hepatic ischemia and reperfusion: Experimental study in rats", EUR SURG RE, 32(4), 2000, pp. 215-222

Abstract

Background/Aims: Some studies have shown that post-ischemic hepatic dysfunction is mainly due to oxygen free radicals that are generated by xanthine oxidase. The present study was undertaken to determine the effect of allopurinol, an inhibitor of xanthine oxidase, on oxidative stress, liver injury and histologic alterations induced by hepatic ischemia-reperfusion in rats. Methods: One hundred and sixty Wistar rats were used and divided into three groups. Group 1: sham operation; group 2: 50 min of ischemia followed by 1 h of reperfusion, and group 3: pretreatment with allopurinol and 50 min of ischemia followed by 1 h of reperfusion. The effect of allopurinol was evaluated by plasma levels of alanine aminotransferase and aspartate aminotransferase, histopathologic studies, and lipid peroxidation measured by the thiobarbituric acid reactive substances method and chemiluminescence initiated by tert-butyl hydroperoxide technique. Results: Ischemia followed by reperfusion promoted an increase in lipid peroxidation of the hepatic cells when compared to the sham-operated group (p < 0.05). This increase was attenuated in the group treated with allopurinol (p < 0.05). Allopurinol also showed a protective effect on hepatocellular necrosis (p < 0.05), and the plasma levels of liver enzymes returned earlier to the normal range in rats pretreated with allopurinol in comparison to those that did not receive the drug (p < 0.05). Conclusions: Allopurinol exerted a protective effect on hepatic ischemia and reperfusion in rats. The administration of this drug priorto liver operations should be considered to be submitted to trials in humans. Copyright (C) 2000 S. Karger AG, Basel.

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Documento generato il 30/03/20 alle ore 19:20:24