Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Interaction of vitamin C with the relation between smoking and obstructiveairways disease in EPIC Norfolk
Autore:
Sargeant, LA; Jaeckel, A; Wareham, NJ;
Indirizzi:
Univ Cambridge, Inst Publ Hlth, Dept Publ Hlth & Primary Care, Cambridge CB2 2SR, England Univ Cambridge Cambridge England CB2 2SR are, Cambridge CB2 2SR, England
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 3, volume: 16, anno: 2000,
pagine: 397 - 403
SICI:
0903-1936(200009)16:3<397:IOVCWT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUTRITION-EXAMINATION-SURVEY; LUNG-FUNCTION; RESPIRATORY SYMPTOMS; PULMONARY-FUNCTION; NATIONAL-HEALTH; DIETARY-INTAKE; DESIGN; ASTHMA;
Keywords:
eepidemiology; interaction; obstructive airways disease; smoking; vitamin C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Wareham, NJ Univ Cambridge, Inst Publ Hlth, Dept Publ Hlth & Primary Care,Robinson Way, Cambridge CB2 2SR, England Univ Cambridge Robinson Way Cambridge England CB2 2SR England
Citazione:
L.A. Sargeant et al., "Interaction of vitamin C with the relation between smoking and obstructiveairways disease in EPIC Norfolk", EUR RESP J, 16(3), 2000, pp. 397-403

Abstract

Previous studies have reported an association between plasma vitamin C levels and respiratory function, but have not examined the role of vitamin C as an effect modifier of the relation between cigarette smoking and obstructive airways disease (OAD). This question was investigated in a cross-sectional analysis of a population-based study of 3,714 males and 4,256 females aged 45-74 yrs, UndiagnosedOAD was defined as a forced expiratory volume in one second (FEV1) of <80%of the predicted value and FEV1/forced vital capacity of <70% without self-reported OAD,An increase of 20 mu mol.L-1 (or 1 SD) in plasma vitamin C concentration was associated,vith a 13% reduction in the risk of having OAD (adjusted oddsratio (OR) (95% confidence interval) 0.87 (0.77-0.98)). The OR for currentsmokers relative to never smokers within the lowest quintile of plasma vitamin C concentration was 5.93 (3.03-11.61). The risk in the upper four quintiles was 2.84 (1.92-4.19). Within the lowest quintile of plasma vitamin C concentration, the risk in former smokers was strongly related to the time since quitting (interaction significant, p=0.001). These findings support a protective role for vitamin C against the risk ofobstructive airways disease and support the hypothesis that vitamin C may be an effect modifier for the adverse effects of smoking on the risk of obstructive airways disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 06:52:52