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Titolo:
Stress in schizophrenia: an integrative view
Autore:
Gispen-de Wied, CC;
Indirizzi:
Univ Utrecht, Med Ctr, Dept Psychiat A01 126, Rudolf Magnus Inst Neurosci,NL-3508 GA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 GA 3508 GA Utrecht, Netherlands
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-3, volume: 405, anno: 2000,
pagine: 375 - 384
SICI:
0014-2999(20000929)405:1-3<375:SISAIV>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIRST-EPISODE SCHIZOPHRENIA; SOLUBLE CYTOKINE RECEPTORS; LUMBAR PUNCTURE STRESS; PLASMA-LEVELS; VENTRICULAR ENLARGEMENT; ELECTRODERMAL ACTIVITY; PSYCHIATRIC-PATIENTS; ONSET SCHIZOPHRENIA; PREPULSE INHIBITION; CLOZAPINE TREATMENT;
Keywords:
schizophrenia; stress; cognition; coping; hypothalamic-pituitary-adrenal system; immune system;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
114
Recensione:
Indirizzi per estratti:
Indirizzo: Gispen-de Wied, CC Univ Utrecht, Med Ctr, Dept Psychiat A01 126, Rudolf Magnus Inst Neurosci,POB 85500, NL-3508 GA Utrecht, Netherlands Univ Utrecht POB 85500 Utrecht Netherlands NL-3508 GA
Citazione:
C.C. Gispen-de Wied, "Stress in schizophrenia: an integrative view", EUR J PHARM, 405(1-3), 2000, pp. 375-384

Abstract

Stress and the development of a (schizophrenic) psychosis are inextricablyrelated. The process by which stress actually affects psychosis is far less clear. The hypothalamic-pituitary-adrenal system, and in particular the release of corticosteroids, has been attributed an essential role. However, schizophrenia is a disorder in which many functions are distorted. Dysfunctions can be found in behavior, cognition, coping, physiology, pituitary-adrenal and immune functioning. In this short paper, these functions are discussed as to how they contribute to the way stress is appraised and processed. Schizophrenic patients are impaired in their biological response to stress by showing a blunted cortisol response to psychosocial stress. It is hypothesized that this reflects rather cognitive dysfunction, based on biological dysfunctions in those brain structures that are responsible for these processes, i.e, the prefrontal cortex and the limbic system. Considering the blunted cortisol response as a maladaptive stress response, its consequences are commented on with an emphasis on the immune system. Finally, the roleof neuroleptics, and in particular the atypical ones, is discussed for their beneficial effect, beyond their fear-and anxiety-reducing properties, inrestoring some of the cognitive dysfunctions schizophrenic patients display. By doing so, they may improve perception of the environment, enhance adjustment and thus a proper stress response. Integration of these processes in stress research described, may provide new vistas of the stress concept in schizophrenia. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 13:55:52