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Titolo:
Long-lasting stress sensitisation
Autore:
Slam, R; Bruijnzeel, AW; Wiegant, VM;
Indirizzi:
Univ Utrecht, Med Ctr, Rudolf Magnus Inst Neurosci, Med Pharmacol Grp, NL-3508 TA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 TA 3508 TA Utrecht, Netherlands
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-3, volume: 405, anno: 2000,
pagine: 217 - 224
SICI:
0014-2999(20000929)405:1-3<217:LSS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; POSITRON-EMISSION-TOMOGRAPHY; VIETNAM COMBAT VETERANS; PITUITARY-ADRENAL AXIS; CHILDHOOD SEXUAL ABUSE; SINGLE SOCIAL DEFEAT; DETROIT AREA SURVEY; INDUCED SENSITIZATION; MALE-RATS; DEXAMETHASONE SUPPRESSION;
Keywords:
behaviour; autonomic response; endocrine response; anxiety; affective disorder; post-traumatic stress disorder (PTSD); (rat);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
98
Recensione:
Indirizzi per estratti:
Indirizzo: Wiegant, VM Univ Utrecht, Med Ctr, Rudolf Magnus Inst Neurosci, Med Pharmacol Grp, POB80040, NL-3508 TA Utrecht, Netherlands Univ Utrecht POB 80040 Utrecht Netherlands NL-3508 TA erlands
Citazione:
R. Slam et al., "Long-lasting stress sensitisation", EUR J PHARM, 405(1-3), 2000, pp. 217-224

Abstract

Stressful experiences in humans can result in a spectrum of long-term changes in behavioural, autonomic and hormonal responsivity. An extreme form ofsuch alterations is found in patients with post-traumatic stress disorder (PTSD). A number of animal models has been developed in which intense stressful experiences (shocks, social confrontations) result in longterm alteredresponsivity of behavioural, autonomic and hormonal responses to aversive challenges which mimic many of the changes seen in PTSD. These models of stress-induced sensitisation are beginning to generate a better understandingof the vulnerability factors, time-course and underlying neuronal substrates of the long-term disturbances experienced by humans as a result of stressful life events. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:29:54