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Titolo:
Role of melanocortins in the central control of feeding
Autore:
Vergoni, AV; Bertolini, A;
Indirizzi:
Univ Modena, Dept Biomed Sci, Pharmacol Sect, I-41100 Modena, Italy Univ Modena Modena Italy I-41100 , Pharmacol Sect, I-41100 Modena, Italy
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-3, volume: 405, anno: 2000,
pagine: 25 - 32
SICI:
0014-2999(20000929)405:1-3<25:ROMITC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRESS-INDUCED ANOREXIA; RECEPTOR ANTAGONIST HS014; CORTICOTROPIN-RELEASING FACTOR; STIMULATING-HORMONE RECEPTOR; AGOUTI OBESITY SYNDROME; MOLECULAR-CLONING; MC4 RECEPTOR; FOOD-INTAKE; MELANOTROPIC PEPTIDE; SELECTIVE ANTAGONIST;
Keywords:
melanocortin; feeding; central nervous system; behavior; body weight homeostasis; anorexia; obesity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Vergoni, AV Univ Modena, Dept Biomed Sci, Pharmacol Sect, Via G Campi 287,I-41100 Modena, Italy Univ Modena Via G Campi 287 Modena Italy I-41100 odena, Italy
Citazione:
A.V. Vergoni e A. Bertolini, "Role of melanocortins in the central control of feeding", EUR J PHARM, 405(1-3), 2000, pp. 25-32

Abstract

The injection of a melanocortin peptide or of melanocortin peptide analogues into the cerebrospinal fluid or into the ventromedial hypothalamus in nanomolar or subnanomolar doses induces a long-lasting inhibition of food intake. The effect keeps significant for up to 9 h and has been observed in all animal species so far tested, the most susceptible being the rabbit. The anorectic effect of these peptides is a primary one, not secondary to the shift towards other components of the complex melanocortin-induced behavioral syndrome, in particular grooming. The site of action is in the brain, andthe effect is not adrenal-mediated because it is fully exhibited also by adrenalectomized animals. It is a very strong effect, because the degree of feeding inhibition is not reduced in conditions of hunger, either induced by 24 h starvation, or by insulin-induced hypoglycemia, or by stimulation ofgamma-aminobutyric acid (GABA), noradrenergic or opioid systems. The microstructural analysis of feeding behavior suggests that melanocortins act as satiety-inducing agents, because they do not significantly modify the latencies to start eating, but shorten the latencies to stop eating. The mechanism of action involves the activation of melanocortin MC4 receptors, becauseselective melanocortin MC4 receptor antagonists inhibit the anorectic effect of melanocortins, while inducing per se a strong stimulation of food intake and a significant increase in body weight. Melanocortins seem to play an important role in stress-induced anorexia, because such condition, in rats, is significantly attenuated by the blockage of melanocortin MC4 receptors; such a role is not secondary to an increased release of corticotropin-releasing factor (CRF), because, on the other hand, the CRF-induced anorexia is not affected at all by the blockage of melanocortin MC4 receptors. The physiological meaning of the feeding inhibitory effect of melanocortins, and, by consequence, the physiological role of melanocortins in the complex machinery responsible for body weight homeostasis, is testified by the hyperphagia/obesity syndromes caused by mutations in the pro-opiomelano-cortin (POMC) gene, or in the melanocortin MC4 receptor gene, or in the agouti locus. Finally, recent evidences suggest that melanocortins could be involved inmediating the effects of leptin, and in controlling the expression of neuropeptide Y (NPY). (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 19:26:51