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Titolo:
Differential effects of stimulants on monoaminergic transporters: Pharmacological consequences and implications for neurotoxicity
Autore:
Fleckenstein, AE; Gibb, JW; Hanson, GR;
Indirizzi:
Univ Utah, Dept Pharmacol & Toxicol, Salt Lake City, UT 84112 USA Univ Utah Salt Lake City UT USA 84112 xicol, Salt Lake City, UT 84112 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 406, anno: 2000,
pagine: 1 - 13
SICI:
0014-2999(20001006)406:1<1:DEOSOM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; HUMAN DOPAMINE TRANSPORTER; TYROSINE-HYDROXYLASE ACTIVITY; METHAMPHETAMINE-INDUCED CHANGES; SEROTONIN UPTAKE SITES; RAT-BRAIN; STRIATAL DOPAMINE; QUANTITATIVE AUTORADIOGRAPHY; NEUROCHEMICAL DEFICITS; FUNCTIONAL REGULATION;
Keywords:
psychostimulant; dopamine trasporter; amphetamine;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
103
Recensione:
Indirizzi per estratti:
Indirizzo: Fleckenstein, AE Univ Utah, Dept Pharmacol & Toxicol, 30 S 2000 E,Rm 201, Salt Lake City, UT 84112 USA Univ Utah 30 S 2000 E,Rm 201 Salt Lake City UTUSA 84112
Citazione:
A.E. Fleckenstein et al., "Differential effects of stimulants on monoaminergic transporters: Pharmacological consequences and implications for neurotoxicity", EUR J PHARM, 406(1), 2000, pp. 1-13

Abstract

Many psychostimulants alter plasmalemmal monoaminergic transporter function. Some, such as cocaine, prevent the reuptake of newly released dopamine, serotonin or norepinephrine into their associated neurons. Others, such as the amphetamines, facilitate release of these transmitters into the extraneuronal space by causing a reversal of function of these carrier proteins. An understanding of how psychostimulants regulate the function of not only plasmalemmal, but also vesicular monoamine transporter function is importantto appreciate the pharmacological and sometimes neurotoxic consequences ofadministering these drugs, as well as the physiological regulation of these carrier proteins. Hence, this review will describe recent ex vivo studiesinvestigating the rapid and differential affects of several stimulants on both plasmalemmal and vesicular monoamine transporter function. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 20:27:35