Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Histologic peripheral nerve changes in rats induced by deltamethrin
Autore:
Calore, EE; Cavaliere, MJ; Puga, FR; Calore, NMP; da Rosa, AR; Weg, R; Dias, SD; dos Santos, RP;
Indirizzi:
Univ Sao Paulo, Sch Vet Med, Dept Pathol, Sao Carlos, SP, Brazil Univ Sao Paulo Sao Carlos SP Brazil Dept Pathol, Sao Carlos, SP, Brazil Univ Sao Paulo, Publ Hlth Fac, Sao Carlos, SP, Brazil Univ Sao Paulo Sao Carlos SP Brazil ubl Hlth Fac, Sao Carlos, SP, Brazil Univ Sao Paulo, Inst Biomed, Dept Pharmacol, Sao Carlos, SP, Brazil Univ Sao Paulo Sao Carlos SP Brazil pt Pharmacol, Sao Carlos, SP, Brazil Inst Emilio Ribas, Pathol Sect, Sao Paulo, Brazil Inst Emilio Ribas Sao Paulo Brazil ibas, Pathol Sect, Sao Paulo, Brazil Inst Adolfo Lutz, Div Pathol, Sao Paulo, Brazil Inst Adolfo Lutz Sao Paulo Brazil o Lutz, Div Pathol, Sao Paulo, Brazil Inst Biol, Toxicol Sect, Sao Paulo, Brazil Inst Biol Sao Paulo BrazilInst Biol, Toxicol Sect, Sao Paulo, Brazil
Titolo Testata:
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
fascicolo: 1, volume: 47, anno: 2000,
pagine: 82 - 86
SICI:
0147-6513(200009)47:1<82:HPNCIR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
TARGET;
Keywords:
nerve; neuropathy; insecticides; pyrethroids; toxicity; deltamethrin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Calore, EE Univ Sao Paulo, Sch Vet Med, Dept Pathol, Sao Carlos, SP, Brazil Univ Sao Paulo Sao Carlos SP Brazil l, Sao Carlos, SP, Brazil
Citazione:
E.E. Calore et al., "Histologic peripheral nerve changes in rats induced by deltamethrin", ECOTOX ENV, 47(1), 2000, pp. 82-86

Abstract

Synthetic pyrethroid insecticides have been used in the last two decades largely because of their high activity as an insecticide and tom mammalian toxicity. Some studies have demonstrated that these products, especially compounds with an a-cyano group, are toxic to the mammalian central nervous system (CNS) in acute intoxications. However, morphological studies are scarce. In the present work the histopathologic changes of the sciatic and tibial nerves of rats submitted to acute intoxication with the cyanopyrethroid deltamethrin were studied. For 3 consecutive days male Wistar rats received by oral gavage deltamethrin at a dose of 45 mg/kg body mt. On the 4th day fragments of sciatic and tibial nerves were studied by transmission electronmicroscopy (TEM) and teasing of individual nerve fibers. In addition, another group of rats mere allowed to recover until the 10th day. Teasing of nerves of animals sacrificed on the 4th day revealed myelin ovoids, which areindicative of axonal damage. TER I demonstrated rare degenerated axons completely filled with organelles, in particular mitochondria, and with electron-dense lamellar bodies that resemble myelin figures. In addition, great cytoplasmic vacuolization caused by proliferation and dilation of the rough and smooth endoplasmic reticulum and Golgi apparatus mas observed in some Schwann cells. No lesion was found 7 days after discontinuation of the treatment (group 2). Since these histologic changes are transitory and scarce, the question arises: Are they related to the changes in NA(+), K+-ATPase activity or Na+ channels caused by pyrethroid compounds? (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/02/20 alle ore 05:18:27