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Titolo:
Effects of NADH and H2O2 on chromate-induced human erythrocytes hemoglobinoxidation and peroxidation
Autore:
Fernandes, MAS; Geraldes, CFGC; Oliveira, CR; Alpoim, MC;
Indirizzi:
Univ Coimbra, Fac Ciencias, Dept Zool, P-3004517 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3004517 ool, P-3004517 Coimbra, Portugal Univ Coimbra, Fac Ciencias, Dept Bioquim, P-3001401 Coimbra, Portugal UnivCoimbra Coimbra Portugal P-3001401 uim, P-3001401 Coimbra, Portugal Univ Coimbra, Fac Med, Serv Bioquim, P-3004504 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3004504 uim, P-3004504 Coimbra, Portugal
Titolo Testata:
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
fascicolo: 1, volume: 47, anno: 2000,
pagine: 39 - 42
SICI:
0147-6513(200009)47:1<39:EONAHO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
REDUCTION;
Keywords:
chromate; human erythrocytes; hemoglobin oxidation; H2O2; NADH; peroxidation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Fernandes, MAS Univ Coimbra, Fac Ciencias, Dept Zool, P-3004517 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3004517 Coimbra, Portugal
Citazione:
M.A.S. Fernandes et al., "Effects of NADH and H2O2 on chromate-induced human erythrocytes hemoglobinoxidation and peroxidation", ECOTOX ENV, 47(1), 2000, pp. 39-42

Abstract

The effects of NADH and H2O2 on chromate-induced human erythrocyte hemoglobin oxidation and peroxidation were studied. It was observed that NADH decreases the levels of chromate-induced human erythrocyte hemoglobin oxidationand peroxidation. H2O2 decreases the levels of chromate-induced hemoglobinoxidation, but increases the levels of chromate-induced peroxidation. The ability of H2O2 to decrease the levels of chromate-induced hemoglobin oxidation is higher than that observed for NADH. Furthermore, H2O2 increases theinhibitory effect of NADH on chromate-induced hemoglobin oxidation, but decreases the NADH effect on chromate-induced peroxidation. The meaning of these results is discussed in terms of involvement of reactive chromium(V) species and reactive oxygen species in the mechanism by which chromate induces its effects in human erythrocytes. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:05:01