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Titolo:
Modeling the interplay of generic and genetic mechanisms in cleavage, blastulation, and gastrulation
Autore:
Drasdo, D; Forgacs, G;
Indirizzi:
Clarkson Univ, Dept Phys & Biol, Potsdam, NY 13699 USA Clarkson Univ Potsdam NY USA 13699 ept Phys & Biol, Potsdam, NY 13699 USA Univ Leipzig, Inst Med Informat Stat & Epidemiol, D-7010 Leipzig, Germany Univ Leipzig Leipzig Germany D-7010 & Epidemiol, D-7010 Leipzig, Germany Univ Missouri, Dept Phys & Biol, Columbia, MO USA Univ Missouri Columbia MO USA ssouri, Dept Phys & Biol, Columbia, MO USA
Titolo Testata:
DEVELOPMENTAL DYNAMICS
fascicolo: 2, volume: 219, anno: 2000,
pagine: 182 - 191
SICI:
1058-8388(200010)219:2<182:MTIOGA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-SHAPE CHANGES; PRIMARY INVAGINATION; EMBRYONIC-TISSUES; MORPHOGENESIS; DROSOPHILA; MEMBRANES; PATTERN;
Keywords:
blastula; gastrulation; physical mechanisms; computer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Forgacs, G Clarkson Univ, Dept Phys & Biol, Potsdam, NY 13699 USA ClarksonUniv Potsdam NY USA 13699 Biol, Potsdam, NY 13699 USA
Citazione:
D. Drasdo e G. Forgacs, "Modeling the interplay of generic and genetic mechanisms in cleavage, blastulation, and gastrulation", DEV DYNAM, 219(2), 2000, pp. 182-191

Abstract

Early development of multicellular organisms is marked by a rapid initial increase in their cell numbers, accompanied by spectacular morphogenetic processes leading to the gradual formation of organs of characteristic shapes. During morphogenesis, through differentiation under strict genetic control, cells become more and more specialized. Morphogenesis also requires coordinated cell movement and elaborate interactions between cells, governed byfundamental physical or generic principles. As a consequence, early development must rely on an intricate interplay of generic and genetic mechanisms, We present the results of computer simulations of the first nontrivial morphogenetic transformations in the life of multicellular organisms: initialcleavages, blastula formation, and gastrulation, The same model, which is based on the physical properties of individual cells and their interactions, describes all these processes. The genetic code determines the values of the model parameters. The model accurately reproduces the major steps of early development. It predicts that physical constraints strongly influence the timing of gastrulation. Gastrulation must occur prior to the appearance of dynamical instability, which would destabilize and eventually derail normal development, Within our model, to avoid the instability, we suddenly change the values of some of the model parameters. We interpret this change as a consequence of specific gene activity. After changing the physical characteristics of some cells, normal development resumes, and gastrulation proceeds. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:23:59