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Titolo:
Simultaneous up-regulation of urokinase-type plasminogen activator (uPA) and uPA receptor by hepatocyte growth factor/scatter factor in human glioma cells
Autore:
Moriyama, T; Kataoka, H; Hamasuna, R; Yoshida, E; Sameshima, T; Iseda, T; Yokogami, K; Nakano, S; Koono, M; Wakisaka, S;
Indirizzi:
Miyazaki Med Coll, Dept Pathol 2, Kiyotake, Miyazaki 8891692, Japan Miyazaki Med Coll Kiyotake Miyazaki Japan 8891692 Miyazaki 8891692, Japan Miyazaki Med Coll, Dept Neurosurg, Kiyotake, Miyazaki 8891692, Japan Miyazaki Med Coll Kiyotake Miyazaki Japan 8891692 Miyazaki 8891692, Japan Miyazaki Med Coll, Dept Physiol 2, Kiyotake, Miyazaki 8891692, Japan Miyazaki Med Coll Kiyotake Miyazaki Japan 8891692 Miyazaki 8891692, Japan
Titolo Testata:
CLINICAL & EXPERIMENTAL METASTASIS
fascicolo: 10, volume: 17, anno: 1999,
pagine: 873 - 879
SICI:
0262-0898(1999)17:10<873:SUOUPA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR SCATTER FACTOR; IN-VITRO; C-MET; FACTOR EXPRESSION; FACTOR HGF; INVASION; MOTILITY; SYSTEM; CANCER; TUMOR;
Keywords:
glioblastoma; hepatocyte growth factor; urokinase-type plasminogen activator (uPA); uPA receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Kataoka, H Miyazaki Med Coll, Dept Pathol 2, 5200 Kihara, Kiyotake, Miyazaki 8891692,Japan Miyazaki Med Coll 5200 Kihara Kiyotake Miyazaki Japan 8891692 n
Citazione:
T. Moriyama et al., "Simultaneous up-regulation of urokinase-type plasminogen activator (uPA) and uPA receptor by hepatocyte growth factor/scatter factor in human glioma cells", CLIN EXP M, 17(10), 1999, pp. 873-879

Abstract

Several lines of evidence indicate that hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, c-Met, may play an important role in progression of human glioma. In this study, effects of HGF/SF on urokinase- typeplasminogen activator (uPA)-mediated proteolysis network were examined in c-Met-positive human glioma cell lines. Treatment of the glioma cells with various concentrations of HGF/SF resulted in an enhanced secretion of uPA proteins accompanying increased transcription of uPA mRNA in a dose dependent fashion. The levels of uPA receptor (uPAR) mRNAs were also elevated simultaneously upon HGF/SF stimulation, and the cell-surface associated uPA activity was also elevated by the treatment. Since concomitant expression of HGF and its receptor c-Met are frequently observed in malignant gliomas, these results suggest that HGF/SF participates in invasive process of malignantglioma cells not only by its motility-stimulating activity but also through enhanced degradation of the extracellular matrix induced by autocrine activation of uPA proteolysis network.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 18:06:11