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Titolo:
Early assessment of myocardial salvage by contrast-enhanced magnetic resonance imaging
Autore:
Hillenbrand, HB; Kim, RJ; Parker, MA; Fieno, DS; Judd, RM;
Indirizzi:
Northwestern Univ, Sch Med, Feinberg Cardiovasc Res Inst, Dept Med, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 t, Dept Med, Chicago, IL 60611 USA Northwestern Univ, Sch Med, Feinberg Cardiovasc Res Inst, Dept Biomed Engn, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 Biomed Engn, Chicago, IL 60611 USA
Titolo Testata:
CIRCULATION
fascicolo: 14, volume: 102, anno: 2000,
pagine: 1678 - 1683
SICI:
0009-7322(20001003)102:14<1678:EAOMSB>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY REPERFUSION; INFARCT SIZE; DOGS; CONTRACTILE; OCCLUSION; EXTENT; TRIAL; ASSET;
Keywords:
magnetic resonance imaging; contrast media; myocardial infarction; salvage therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Judd, RM Northwestern Univ, Sch Med, Feinberg Cardiovasc Res Inst, Dept Med, 303 E Chicago Ave,Tarry 12-723, Chicago, IL 60611 USA Northwestern Univ 303 E Chicago Ave,Tarry 12-723 Chicago IL USA 60611
Citazione:
H.B. Hillenbrand et al., "Early assessment of myocardial salvage by contrast-enhanced magnetic resonance imaging", CIRCULATION, 102(14), 2000, pp. 1678-1683

Abstract

Background-Myocardial salvage after acute myocardial infarction is definedclinically by early restoration of flow and long-term improvement in contractile function. We hypothesized that contrast-enhanced magnetic resonance imaging (MRI), performed early after myocardial infarction, indexes myocardial salvage. We studied the relationship between the transmural extent of hyperenhancement by contrast-enhanced MRI, restoration of flow, and recoveryof function. Methods and Results-The left anterior descending coronary artery was occluded in dogs (n=15) for either 45 minutes, 90 minutes, or permanently. Cine and contrast-enhanced MRI were performed 3 days after the procedure; cine MRI was also done 10 and 28 days after the procedure. The transmural extent of hyperenhancement and wail thickening were determined using a 60-segment model. The mean transmural extent of hyperenhancement for the 45-minute occlusion group was 22% of the 90-minute group and 18% of the permanent occlusion group (P<0.05 for both). The transmural extent of hyperenhancement on day 3 was related to future improvement in both wall thickening score and absolute wall thickening at 10 and 28 days (P<0.0001 for each). For example, of the 415 segments on day 3 that were dysfunctional and had <25% transmural hyperenhancement, 362. (87%) improved by day 28. Conversely, no segments (0 of 9) with 100% hyperenhancement improved. The transmural extent of hyperenhancement on day 3 was a better predictor of improvement in contractile function than occlusion time (P<0.0001). Conclusions-A reduction in the transmural extent of hyperenhancement by contrast-enhanced MRI early after myocardial infarction is associated with anearly restoration of flow and future improvement in contractile function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 20:07:00