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Titolo:
Pd(II) complexes mediated hydrolytic cleavage of insulin B chain: Regioselectivity and influence of peptide secondary structure
Autore:
Luo, XM; He, WJ; Zhang, Y; Guo, ZJ; Zhu, LG;
Indirizzi:
Nanjing Univ, Inst Coordinat Chem, State Key Lab Coordinat Chem, Nanjing 210093, Peoples R China Nanjing Univ Nanjing Peoples R China 210093 jing 210093, Peoples R China
Titolo Testata:
CHEMISTRY LETTERS
fascicolo: 9, , anno: 2000,
pagine: 1030 - 1031
SICI:
0366-7022(20000905):9<1030:PCMHCO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHIONINE-CONTAINING DIPEPTIDES; HISTIDINE-CONTAINING PEPTIDES; PALLADIUM(II) AQUA COMPLEXES; COPPER(II); LIGANDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Zhu, LG Nanjing Univ, Inst Coordinat Chem, State Key Lab Coordinat Chem, Nanjing 210093, Peoples R China Nanjing Univ Nanjing Peoples R China 210093 093, Peoples R China
Citazione:
X.M. Luo et al., "Pd(II) complexes mediated hydrolytic cleavage of insulin B chain: Regioselectivity and influence of peptide secondary structure", CHEM LETT, (9), 2000, pp. 1030-1031

Abstract

Electrospray mass spectrometry studies show that the binding of Pd(II) complexes and the site of cleavage are highly dependent on the secondary structure and local environment of oxidized insulin B chain (B). The hydrolytic cleavage of denatured B by Pd(II) complexes is monitored by HPLC, which follows first order kinetics with half-life of 4.8 days at 40 degrees C. Two amide bonds at Leu6-Cys7 and Gly8-Ser9 are selectively cleaved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 01:08:22