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Titolo:
Neuronal life and death: an essential role for the p53 family
Autore:
Miller, FD; Pozniak, CD; Walsh, GS;
Indirizzi:
McGill Univ, Montreal Neurol Inst, Ctr Neuronal Survival, Montreal, PQ H3A2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 vival, Montreal, PQ H3A2B4, Canada
Titolo Testata:
CELL DEATH AND DIFFERENTIATION
fascicolo: 10, volume: 7, anno: 2000,
pagine: 880 - 888
SICI:
1350-9047(200010)7:10<880:NLADAE>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED CELL-DEATH; TUMOR-SUPPRESSOR P53; TROPHIC FACTOR DEPRIVATION; KILLS POSTMITOTIC NEURONS; CENTRAL-NERVOUS-SYSTEM; SYMPATHETIC NEURONS; INDUCED APOPTOSIS; GROWTH-FACTOR; CYTOSINE-ARABINOSIDE; ALZHEIMERS-DISEASE;
Keywords:
P53; P73; neuronal apoptosis; neurotrophins; DNA damage; excitotoxicity; oxidative stress; neurodegeneration; ischaemia cell cycle;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
127
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, FD McGill Univ, Montreal Neurol Inst, Ctr Neuronal Survival, 3801 Rue Univ, Montreal, PQ H3A 2B4, Canada McGill Univ 3801 Rue Univ Montreal PQ Canada H3A 2B4 B4, Canada
Citazione:
F.D. Miller et al., "Neuronal life and death: an essential role for the p53 family", CELL DEAT D, 7(10), 2000, pp. 880-888

Abstract

Recent evidence indicates that the p53 tumor suppressor protein, and its related family member, p73, play an essential role in regulating neuronal apoptosis in both the developing and injured, mature nervous system. In the developing nervous system, they do so by regulating naturally-occurring celldeath in neural progenitor cells and in postmitotic neurons, acting to ensure the apoptosis of cells that either do not appropriately undergo the progenitor to postmitotic neuron transition, or that fail to compete for sufficient quantities of trophic support. Somewhat surprisingly, in developing postmitotic neurons, p53 plays a proapoptotic role, while a naturally-occurring, truncated form of p73, Delta Np73, antagonizes p53 and plays an anti-apoptotic role. In the mature nervous system, numerous studies indicate thatp53 is essential for the neuronal death in response to a variety of insults, including DNA damage, ischemia and excitotoxicity. It is likely that allof these insults culminate in DNA damage, which may well be a common trigger for neuronal apoptosis, In this regard, the signaling pathways that are responsible for triggering p53 dependent neuronal apoptosis are starting tobe elucidated, and involve cell cycle deregulation and activation of the JNK pathway, Finally, accumulating evidence indicates that p53 is perturbed in the CNS in a number of neurodegenerative disorders, leading to the hypothesis that longterm oxidative damage and/or excitotoxicity ultimately trigger p53 dependent apoptosis in the chronically degenerating nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 12:35:36