Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
P21 gene expression as an indicator for the activity of adenovirus-p53 gene therapy in non-small cell lung cancer patients
Autore:
Boulay, JL; Perruchoud, AP; Reuter, J; Bolliger, C; Herrmann, R; Rochlitz, C;
Indirizzi:
Univ Basel Hosp, Div Oncol, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 ol, CH-4031 Basel, Switzerland Univ Basel Hosp, Div Pneumol, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 ol, CH-4031 Basel, Switzerland
Titolo Testata:
CANCER GENE THERAPY
fascicolo: 9, volume: 7, anno: 2000,
pagine: 1215 - 1219
SICI:
0929-1903(200009)7:9<1215:PGEAAI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR SUPPRESSION; P53 GENE;
Keywords:
cancer; gene therapy; p53; chemotherapy; clinical trial;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Boulay, JL Univ Basel Hosp, Div Oncol, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 Basel, Switzerland
Citazione:
J.L. Boulay et al., "P21 gene expression as an indicator for the activity of adenovirus-p53 gene therapy in non-small cell lung cancer patients", CANC GENE T, 7(9), 2000, pp. 1215-1219

Abstract

Alterations in the tumor suppressor gene p53 lead to impaired cell cycle control, allowing for the development and growth of tumors. To restore a loss of p53 function, we performed a phase I study of intratumoral gene therapy with adenovirus expressing wild-type p53 in patients with non-small cell lung cancer carrying mutations in the p53 gene. Furthermore, in a phase II study, gene therapy was complemented with simultaneous cisplatin/vinorelbine treatment. Biopsies were obtained from all treated patients before and 24-48 hours after gene therapy to study changes in the expression of p53 target genes. We report here that in most of the cases, the target gene p21 wasup-regulated, especially when injection of higher doses of p53-expressing adenovirus was combined with simultaneous chemotherapy, whereas Pig3, previously reported to be highly up-regulated by p53, generally did not show a clear increase. Interestingly, a clear p21 gene response was observed only in tumors showing stabilization or regression. We conclude that p21 appears to be up-regulated after adenovirus-mediated p53 gene transfer and is the most sensitive marker tested for biological response to gene therapy in the small cohort of non-small cell lung cancers that were studied.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:14:42