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Titolo:
Neurotransmitter changes in the pathophysiology of Lesch-Nyhan syndrome
Autore:
Saito, Y; Takashima, S;
Indirizzi:
Natl Ctr Neurol & Psychiat, Dept Mental Retardat & Birth Defect Res, Tokyo, Japan Natl Ctr Neurol & Psychiat Tokyo Japan & Birth Defect Res, Tokyo, Japan Natl Ctr Neurol & Psychiat, Dept Clin Lab, Tokyo, Japan Natl Ctr Neurol & Psychiat Tokyo Japan iat, Dept Clin Lab, Tokyo, Japan Yokohama Ryo Iku En, Div Child Neurol, Asahi Ku, Yokohama, Kanagawa 2410014, Japan Yokohama Ryo Iku En Yokohama Kanagawa Japan 2410014 nagawa 2410014, Japan
Titolo Testata:
BRAIN & DEVELOPMENT
, , anno: 2000, supplemento:, 1
pagine: S122 - S131
SICI:
0387-7604(200009):<S122:NCITPO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELF-INJURIOUS-BEHAVIOR; POSITRON EMISSION TOMOGRAPHY; RECEPTOR UP-REGULATION; PARKINSONS-DISEASE; BASAL GANGLIA; STRIATONIGRAL DEGENERATION; HUNTINGTONS-DISEASE; DOPAMINE DEFICIENCY; MOUSE MODEL; BRAIN-STEM;
Keywords:
Lesch-Nyhan syndrome; self-mutilation; dopamine; serotonin; receptor supersensitivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
99
Recensione:
Indirizzi per estratti:
Indirizzo: Saito, Y Natl Ctr Neurol & Psychiat, Dept Mental Retardat & Birth Defect Res, Tokyo, Japan Natl Ctr Neurol & Psychiat Tokyo Japan efect Res, Tokyo, Japan
Citazione:
Y. Saito e S. Takashima, "Neurotransmitter changes in the pathophysiology of Lesch-Nyhan syndrome", BRAIN DEVEL, 2000, pp. S122-S131

Abstract

The neurological symptoms of Lesch-Nyhan syndrome (LNS) are assumed to result from the neurotransmitter changes in this disorder. Among them, the dopaminergic system is believed to play a role in the self-injurious behavior through receptor supersensitivity. However, the precise mechanism underlying the dopamine supersensitivity remains unclear. An increased serotonergic action in the striatum may be crucial for the appearance of self-injurious behavior, and pharmacological evidence suggests the efficacy of serotonin agonists/antagonists for the treatment of the self-mutilation in LNS. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 20:02:16