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Titolo:
The pathophysiology of cholestasis with special reference to primary biliary cirrhosis
Autore:
Jansen, PLM;
Indirizzi:
Univ Groningen Hosp, Dept Gastroenterol & Hepatol, NL-9700 RB Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9700 RB ningen, Netherlands Univ Groningen Hosp, Dept Gastroenterol, NL-9700 RB Groningen, NetherlandsUniv Groningen Hosp Groningen Netherlands NL-9700 RB ningen, Netherlands Univ Groningen Hosp, Res Ctr Gastrointestinal & Metab Dis, NL-9700 RB Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9700 RB ningen, Netherlands
Titolo Testata:
BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY
fascicolo: 4, volume: 14, anno: 2000,
pagine: 571 - 583
SICI:
1521-6918(200008)14:4<571:TPOCWS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORGANIC ANION TRANSPORTER; MULTIDRUG-RESISTANCE PROTEIN-2; P-GLYCOPROTEIN GENE; FAMILIAL INTRAHEPATIC CHOLESTASIS; HEPATOCYTE CANALICULAR ISOFORM; BILE-ACID TRANSPORTER; SALT EXPORT PUMP; RAT-LIVER; FUNCTIONAL-CHARACTERIZATION; UP-REGULATION;
Keywords:
cholestasis; P-glycoproteins; multidrug-resistance-associated proteins; hepatocytes; cholangiocytes; primary biliary cirrhosis; transport; bile;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Jansen, PLM Univ Groningen Hosp, Dept Gastroenterol & Hepatol, POB 30-0001, NL-9700 RBGroningen, Netherlands Univ Groningen Hosp POB 30-0001 Groningen Netherlands NL-9700 RB
Citazione:
P.L.M. Jansen, "The pathophysiology of cholestasis with special reference to primary biliary cirrhosis", BEST PR RES, 14(4), 2000, pp. 571-583

Abstract

Cholestasis in primary biliary cirrhosis results from impairment of bile flow either by reduced transport at the level of the canaliculi or by disturbed bile flow through damaged intrahepatic bile ductules. Whatever its cause, the expression of hepatic transport proteins will be affected. In cholestatic rats: the expression of the multispecific organic anion transporter mrp2 is decreased; the bile salt export pump bsep and the phospholipid transporter mdr2 are less affected; the carrier protein for hepatic uptake of bile salts ntcp is sharply down-regulated; Mrp3, a basolateral ATP-dependent transporter for glucuronides and bile salts, is upregulated. Thus, bile salts that cannot exit the hepatocyte because of the cholestasis are effectively removed across the basolateral membrane. These may be adaptive responses in defence against overloading of hepatocytes with cytotoxic bile salts. These responses show that the expression of hepatic transporter proteins is highly regulated. This occurs by transcriptional and post-transcriptional mechanisms. Primary biliary cirrhosis startsas a disease of the small intrahepatic bile ducts and therefore the experimental evidence for 'cross-talk' between hepatocytes and cholangiocytes is of great interest for this disease and needs to be further investigated. New insights in bile physiology may enable the development of new therapies for cholestatic liver diseases as primary biliary cirrhosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 14:21:02