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Titolo:
Does locomotor response to novelty in rats predict susceptibility to develop sensitization to cocaine and PHNO?
Autore:
Djano, S; Martin-Iverson, MT;
Indirizzi:
Univ Western Australia, Dept Psychol, Nedlands, WA 6907, Australia Univ Western Australia Nedlands WA Australia 6907 nds, WA 6907, Australia Univ Western Australia, Dept Pharmacol, Nedlands, WA 6907, Australia Univ Western Australia Nedlands WA Australia 6907 nds, WA 6907, Australia Univ Western Australia, Dept Psychiat & Behav Sci, Nedlands, WA 6907, Australia Univ Western Australia Nedlands WA Australia 6907 nds, WA 6907, Australia Univ Western Australia, Ctr Clin Res Neuropsychiat, Nedlands, WA 6907, Australia Univ Western Australia Nedlands WA Australia 6907 nds, WA 6907, Australia
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 6, volume: 11, anno: 2000,
pagine: 455 - 470
SICI:
0955-8810(200009)11:6<455:DLRTNI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED BEHAVIORAL SENSITIZATION; STRIATAL DOPAMINE RELEASE; REPEATED AMPHETAMINE TREATMENT; INDUCED ROTATIONAL BEHAVIOR; NUCLEUS-ACCUMBENS; CONDITIONED LOCOMOTION; INDIVIDUAL VULNERABILITY; EXTRACELLULAR DOPAMINE; RECEPTOR AGONIST; SEX-DIFFERENCES;
Keywords:
cocaine; PHNO; sensitization; individual differences; novelty; locomotion; rat; addiction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Martin-Iverson, MT Univ Western Australia, Dept Psychol, Nedlands, WA 6907, Australia Univ Western Australia Nedlands WA Australia 6907 alia
Citazione:
S. Djano e M.T. Martin-Iverson, "Does locomotor response to novelty in rats predict susceptibility to develop sensitization to cocaine and PHNO?", BEHAV PHARM, 11(6), 2000, pp. 455-470

Abstract

It has been suggested that the locomotor response of rats to novelty is positively correlated with motor stimulant effects of acute injections with psychomotor stimulants, and liability to self-administer these drugs. In addition, response to novelty appears to be inversely correlated with an individual's susceptibility to develop behavioural sensitization tan increase inthe behavioural response to a given dose of stimulant after repeated treatments). To test some of these putative relationships, 96 rats were allocated to one of two subgroups based on a median split of locomotor responses tonovelty. Animals then received 10 successive injections of either vehicle,cocaine (10 mg/kg), or the direct D-2 agonist, (+)-4-propyl-9-hydroxynaphthoxazine (PHNO: 15 mu g/kg), and locomotor activity was monitored. Conditioning tests and additional sensitization and cross-sensitization tests were conducted. Results showed that locomotor responses to novelty are not significantly correlated with locomotor effects of either acute injection with cocaine or PHNO, or rate of development of behavioural sensitization to these drugs. However, locomotor responses to novelty did predict level of locomotor and stereotypy responses to cocaine, and to a lessor extent to PHNO. Cocaine-treated, but not PHNO-treated, rats exhibited drug-conditioned-like effects. Cross-sensitization between cocaine and PHNO was not observed, indicating independent mechanisms for sensitization. It is concluded that the locomotor response to novelty can predict level of locomotion and stereotypy produced by cocaine and PHNO, but does not predict the degree or rate of behavioural sensitization to either of these drugs. (C) 2000 Lippincott Williams & Wilkins.

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Documento generato il 27/01/20 alle ore 07:24:40