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Titolo:
Peripheral neuropathy associated with anti-GM2 ganglioside antibodies: Clinical and immunopathological studies
Autore:
OHanlon, GM; Veitch, J; Gallardo, E; Illa, I; Chancellor, AM; Willison, HJ;
Indirizzi:
Univ Glasgow, So Gen Hosp, Dept Neurol, Glasgow G51 4TF, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland G51 4TF ow G51 4TF, Lanark, Scotland
Titolo Testata:
AUTOIMMUNITY
fascicolo: 2, volume: 32, anno: 2000,
pagine: 133 - 144
SICI:
0891-6934(2000)32:2<133:PNAWAG>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUILLAIN-BARRE-SYNDROME; MOTOR-NEURON DISEASE; ANTIGANGLIOSIDE ANTIBODIES; IGM ANTIBODIES; CELL-LINE; GAMMOPATHY; PARAPROTEINS; DISORDER; GM2;
Keywords:
peripheral neuropathy; motor neurone disease; paraproteins; GM2 ganglioside; autoantibodies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Willison, HJ Univ Glasgow, So Gen Hosp, Dept Neurol, Glasgow G51 4TF, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland G51 4TF anark, Scotland
Citazione:
G.M. O'Hanlon et al., "Peripheral neuropathy associated with anti-GM2 ganglioside antibodies: Clinical and immunopathological studies", AUTOIMMUN, 32(2), 2000, pp. 133-144

Abstract

GM2 ganglioside is a potential peripheral nerve antigen for neuropathy-associated autoantibodies. However little data are available on their pathogenic effects, if any. In this study we have screened both neuropathy-associated and control sera for anti-GM2 antibodies and subsequently used high titre sera for immunohistological and complement mediated cytotoxicity studies. We identified abnormally elevated anti-GM2 antisera in the normal population, as well as in patients with peripheral neuropathies and other neurological diseases. GM2 antibodies were either mono-reactive, cross-reactive withGM1a, or cross-reactive with GalNAc-GM1b and/or GalNAc-GD1a. All GM2 antisera from neuropathy subjects and normal controls bound to, and were capableof complement-mediated lysis of the NSC-34 cell line which expresses high levels of membrane-associated GM2. However, in immunohistological studies on human and rodent peripheral nervous system tissues, no specific binding was seen with GM2 antisera, either cross-reactive with GalNAc-GM1b and GalNAc-GD1a, or with GM1a. These data indicate that although GM2 antisera can lyse neural membranes containing GM2, this antigen(s) is not detectable by standard immunohistological techniques in human or rodent peripheral nerve. This raises doubts about their pathophysiological significance in human autoimmune neuropathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 12:53:11