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Titolo:
Age dependency of neointima formation on vascular prostheses in dogs
Autore:
Noishiki, Y; Yamane, T; Ichikawa, Y; Yamazaki, I; Yamamoto, K; Kosuge, T; Manabe, T; Mo, M;
Indirizzi:
Yokohama City Univ, Sch Med, Dept Surg, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 anagawa 2360004, Japan Tokyo Univ Agr & Technol, Dept Vet Med, Div Surg, Tokyo 156, Japan Tokyo Univ Agr & Technol Tokyo Japan 156 Med, Div Surg, Tokyo 156, Japan
Titolo Testata:
ARTIFICIAL ORGANS
fascicolo: 9, volume: 24, anno: 2000,
pagine: 718 - 728
SICI:
0160-564X(200009)24:9<718:ADONFO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
POROUS ARTERIAL PROSTHESES; FIBROBLAST GROWTH-FACTOR; ENDOTHELIAL-CELLS; DACRON; PROLIFERATION; PERFORMANCE; GRAFTS; MODEL;
Keywords:
vascular prostheses; neointima formation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Noishiki, Y Yokohama City Univ, Sch Med, Dept Surg, Kanazawa Ku, 3-9 Fukuura, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ 3-9 Fukuura Yokohama Kanagawa Japan 2360004
Citazione:
Y. Noishiki et al., "Age dependency of neointima formation on vascular prostheses in dogs", ARTIF ORGAN, 24(9), 2000, pp. 718-728

Abstract

Neointima formed quickly on vascular prostheses implanted in young dogs but not in aged dogs. Previously, we found that impeding neointima formation on vascular prostheses occurred more frequently in aged animals. From theseobservations, we hypothesized that neointima formation was age-dependent in dogs. To test the hypothesis, 26 fabric Dacron vascular prostheses were analyzed. Half of them were retrieved from aged dogs (more than 13 years old) while the other half were from young ones (less than 1 year old). The grafts were harvested at 8 weeks and 3 months after implantation. The graft surfaces were photographed and analyzed by computer for the ratio of the areas with and without thrombus. Light and scanning electron microscopic observation revealed that most of the thrombus-free areas were lined with endothelial cells. Then the endothelialized areas were calculated. Using data obtained from macroscopic, light microscopic, and scanning electron microscopicobservations, the arithmetic means were calculated as the degree of neointima formation. In young animals, the degrees at 8 weeks and at 3 months were 89.1 +/- 8.5% (mean +/- SD) and 95.7 +/- 3.3%, respectively. In old animals, they were 27.9 +/- 5.9% and 31.5 +/- 6.8%, respectively. From these results, we concluded that neointima formation was age-dependent in dogs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:47:55