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Titolo:
Monotherapy in an era of combination therapy: is there a benefit? Experience in HIV-1-infected symptomatic South African children
Autore:
Pijnenburg, MWH; Cotton, MF;
Indirizzi:
Univ Stellenbosch, Fac Med, Dept Paediat & Child Hlth, ZA-7505 Tygerberg, South Africa Univ Stellenbosch Tygerberg South Africa ZA-7505 Tygerberg, South Africa Univ Groningen Hosp, Beatrix Childrens Hosp, Dept Paediat, Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands ediat, Groningen, Netherlands Tygerberg Hosp, Tygerberg, South Africa Tygerberg Hosp Tygerberg South Africa erg Hosp, Tygerberg, South Africa
Titolo Testata:
ANNALS OF TROPICAL PAEDIATRICS
fascicolo: 3, volume: 20, anno: 2000,
pagine: 185 - 192
SICI:
0272-4936(200009)20:3<185:MIAEOC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS INFECTION; SUB-SAHARAN AFRICA; ZIDOVUDINE; DIDANOSINE; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Cotton, MF Univ Stellenbosch, Fac Med, Dept Paediat & Child Hlth, POB 19063, ZA-7505 Tygerberg, South Africa Univ Stellenbosch POB 19063 Tygerberg South Africa ZA-7505 ica
Citazione:
M.W.H. Pijnenburg e M.F. Cotton, "Monotherapy in an era of combination therapy: is there a benefit? Experience in HIV-1-infected symptomatic South African children", ANN TROP PA, 20(3), 2000, pp. 185-192

Abstract

We investigated the benefit of treating HIV-1-infected children with monotherapy where resources are limited. A retrospective chart review was undertaken in 12 symptomatic HIV-1-infected children treated with zidovudine or didanosine for at least 2 months. The main outcome measure was the effect onhospitalization. Anti-retroviral therapy was commenced in nine children because of prolonged or frequent hospitalization. Of three whose primary indication was bleeding secondary to thrombocytopenia, two had been hospitalized owing to severe intercurrent illness. One child had failure to thrive andanother encephalopathy. Monotherapy was considered beneficial in all cases. Median duration of follow-up was 6.5 (2 - 31) months. The hospitalizationindex (days in hospital before and after start of monotherapy, divided by the total number of days before and after start of monotherapy) decreased from a median of 0.115 prior to therapy to 0.037 on therapy (p=0.045, Wilcoxon matched pairs test). This study presents observational data supporting the investigation of monotherapy in resource-poor countries. It was associated with a significant reduction in hospitalization and appeared to result in clinical improvement. Prolonged or frequent hospitalization might represent a novel indication for use because in our setting the cost of hospitalization could potentially provide a 12-month-old infant with monotherapy for 2 months.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 02:07:53