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Titolo:
Neuronal density in the human retinal ganglion cell layer from 16-77 years
Autore:
Harman, A; Abrahams, B; Moore, S; Hoskins, R;
Indirizzi:
Univ Western Australia, Dept Psychol, Nedlands, WA 6907, Australia Univ Western Australia Nedlands WA Australia 6907 nds, WA 6907, Australia
Titolo Testata:
ANATOMICAL RECORD
fascicolo: 2, volume: 260, anno: 2000,
pagine: 124 - 131
SICI:
0003-276X(20001001)260:2<124:NDITHR>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN OPTIC-NERVE; MONKEY CEREBRAL-CORTEX; RHESUS-MONKEY; ALZHEIMERS-DISEASE; PIGMENT EPITHELIUM; STRIATE CORTEX; RAT RETINA; AGE; TOPOGRAPHY; NUMBER;
Keywords:
aging; human; cell topography; cell death;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Harman, A Univ Western Australia, Dept Psychol, Nedlands, WA 6907, Australia Univ Western Australia Nedlands WA Australia 6907 07, Australia
Citazione:
A. Harman et al., "Neuronal density in the human retinal ganglion cell layer from 16-77 years", ANAT REC, 260(2), 2000, pp. 124-131

Abstract

Literature assessing whether or not neurons (retinal ganglion cells and displaced amacrine cells) are lost from the retinal ganglion cell layer in mammals with age is still controversial, some studies finding a decrease in cell density and others not. To date there have been no studies estimating the total number of neurons in the retinal ganglion cell layer of humans throughout life. Recent studies have concentrated on the macular region and examined cell densities, which are reported to decrease during aging. In a study of the human retinal pigment epithelium (RPE), we showed that, while RPE cell number does not change, cell density increases significantly in central temporal retina (macular region) as the retina ages. We speculated thatthe increase in density represents a "drawing together" of the retinal sheet to maintain high cell densities, in this region of the neural retina, inthe face of presumed cell loss from the ganglion cell layer due to aging. Here, therefore, we have sampled the entire ganglion cell layer of the human retina and estimated total neuron numbers in 12 retinae aged from 16 to 71 years. Human retinae, fixed in formalin, were obtained from the Queensland Eye Bank and whole-mounted, ganglion cell layer uppermost. The total number of neurons was lower in the alder than younger retinae and neuronal density was lower in most retinal regions in older retinae. Retinal area increased with age and neuronal density fell throughout the retina with a mean reduction of 0.53% per year. However, the percentage reduction in density wasmuch lower for the macular region, with a value of 0.29% per year. It is possible that this lesser reduction in cell density in the macula is a result of the drawing together of the retinal sheet in this region as we speculated from RPE data. Anat Rec 260:124-131, 2000. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 01:02:48