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Titolo:
Multivariate assessment of factors influencing illicit substance use in twins from female-female pairs
Autore:
Karkowski, LM; Prescott, CA; Kendler, KS;
Indirizzi:
Virginia Commonwealth Univ, Med Coll Virginia, Dept Psychiat, Richmond, VA23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 t, Richmond, VA23298 USA Virginia Commonwealth Univ, Med Coll Virginia, Dept Human Genet, Richmond,VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 t, Richmond,VA 23298 USA Virginia Commonwealth Univ, Med Coll Virginia, Virginia Inst Psychiat & Behav Genet, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 5, volume: 96, anno: 2000,
pagine: 665 - 670
SICI:
0148-7299(20001009)96:5<665:MAOFII>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
POPULATION-BASED SAMPLE; FAMILIAL TRANSMISSION; DRUG-USE; ABUSE; DEPENDENCE; ALCOHOL; COCAINE; WOMEN;
Keywords:
psychoactive substance use disorder (PSUD); twin study; genetics; familial environment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Karkowski, LM Virginia Commonwealth Univ, Med Coll Virginia, Dept Psychiat, POB 980126, Richmond, VA 23298 USA Virginia Commonwealth Univ POB 980126 Richmond VA USA 23298
Citazione:
L.M. Karkowski et al., "Multivariate assessment of factors influencing illicit substance use in twins from female-female pairs", AM J MED G, 96(5), 2000, pp. 665-670

Abstract

Although familial factors have been shown to influence drug use, abuse, and dependence, little is known about the common and specific factors that influence polysubstance use and misuse. Our objective was to assess whether there are genetic and environmental factors specific to each substance or whether there are factors that predispose an individual to use of illicit substances in general. Twins from female-female pairs from the Virginia Twin Registry were interviewed by phone to assess life-time nonmedical use of cannabis, sedatives, stimulants, cocaine, opiates, and hallucinogens, Multivariate, biometrical model-fitting was applied to the data using the Mx computer package. In the best-fitting model, use of all classes of drugs was influenced by a single general genetic factor (common to all substances) and a general familial environmental factor. The magnitude of influence of the general genetic factor ranged from 3% of the variance for opiates to 59% of the variance for cannabis, Some differences were seen from the univariate results, indicating some of the parameter estimates were unstable due to small numbers of concordant pairs, However, generalizations could be made. In women, the substances examined share genetic and familial environmental factors which contribute to the vulnerability to use. Degree of influence of the factors differs for the substances examined. However, no specific geneticor familial environmental factors were found to contribute significantly to use of any of the illicit substances. Am. J. Med. Genet. (Neuropsychiatr. Genet,) 96:665-670, 2000, (C) 2000 Wiley-Liss, Inc.

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Documento generato il 25/01/20 alle ore 19:08:04