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Titolo:
Family-based study of DRD2 alleles in alcohol and drug dependence
Autore:
Blomqvist, O; Gelernter, J; Kranzler, HR;
Indirizzi:
Univ Connecticut, Sch Med, Alcohol Res Ctr, Dept Psychiat, Farmington, CT 06030 USA Univ Connecticut Farmington CT USA 06030 ychiat, Farmington, CT 06030 USA VA Connecticut Healthcare Syst, W Haven, CT USA VA Connecticut Healthcare Syst W Haven CT USA care Syst, W Haven, CT USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ New Haven CT USA iv, Sch Med, Dept Psychiat, New Haven, CT USA
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 5, volume: 96, anno: 2000,
pagine: 659 - 664
SICI:
0148-7299(20001009)96:5<659:FSODAI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE-RECEPTOR GENE; SUBSTANCE-ABUSE; NO ASSOCIATION; TAQI-A; LINKAGE DISEQUILIBRIUM; HAPLOTYPE FREQUENCIES; COCAINE DEPENDENCE; AFRICAN-AMERICANS; LOCUS; POLYMORPHISMS;
Keywords:
dopamine D2 receptor gene; DRD2; linkage disequilibrium; TDT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Kranzler, HR Univ Connecticut, Sch Med, Alcohol Res Ctr, Dept Psychiat, MC2103,263 Farmington Ave, Farmington, CT 06030 USA Univ Connecticut MC2103,263 Farmington Ave Farmington CT USA 06030
Citazione:
O. Blomqvist et al., "Family-based study of DRD2 alleles in alcohol and drug dependence", AM J MED G, 96(5), 2000, pp. 659-664

Abstract

Numerous case-control studies have addressed the hypothesis that variant alleles of the dopamine D2 receptor gene (DRD2) increase the liability for alcohol and/or drug dependence, and both positive and negative results have been reported, Because population frequencies of these alleles vary considerably, the conflicting results could be due to population stratification bias, Using the transmission disequilibrium test, the present study examined linkage disequilibrium of alcohol and drug (opioid and/or cocaine) dependence with three DRD2 polymorphic systems: (a) TaqI A, (b) TaqI D, and (c) thefunctional -141CIns/Del promoter systems. DNA samples were collected from small nuclear families (SNFs), where one or more offspring met DSM-III-R orDSM-IV criteria for alcohol and/or drug dependence. Because positive association between DRD2 alleles and alcohol and/or drug dependence has been reported only in populations of European ancestry, we limited the present study to European Americans (EAs), No evidence for linkage disequilibrium was found for any of the polymorphic systems when examined in relation to any substance dependence, alcohol dependence (with or without drug dependence), or drug dependence (with or without alcohol dependence). These results are consistent with those from a recent family-based study of alcohol dependence, Together, these studies suggest that the conflicting findings from case-control studies of the association between alleles of DRD2 and substance dependence may be attributable to population stratification in some samples, Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:659-664 2000, (C) 2000 Wiley-Liss, Inc.

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Documento generato il 18/01/20 alle ore 02:03:27