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Titolo:
Antisociality, substance dependence, and the DRD5 gene: A preliminary study
Autore:
Vanyukov, MM; Moss, HB; Kaplan, BB; Kirillova, GP; Tarter, RE;
Indirizzi:
Univ Pittsburgh, Ctr Educ & Drug Abuse Res, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 use Res, Pittsburgh, PA 15261 USA Univ Pittsburgh, Mol Neurobiol & Genet Program, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Program, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Pharmaceut Sci, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 eut Sci, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 sychiat, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 n Genet, Pittsburgh, PA 15261 USA
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 5, volume: 96, anno: 2000,
pagine: 654 - 658
SICI:
0148-7299(20001009)96:5<654:ASDATD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR GENE; ENVIRONMENTAL-INFLUENCES; LINKAGE DISEQUILIBRIUM; ALLELIC ASSOCIATION; DRUG-USE; DOPAMINE; ALCOHOLISM; POLYMORPHISM; BEHAVIOR; DISORDER;
Keywords:
drug abuse; dopamine receptors; genetics; disruptive behavior; gender;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Vanyukov, MM Univ Pittsburgh, Ctr Educ & Drug Abuse Res, 707 Salk Hall, Pittsburgh, PA 15261 USA Univ Pittsburgh 707 Salk Hall Pittsburgh PA USA 15261 261 USA
Citazione:
M.M. Vanyukov et al., "Antisociality, substance dependence, and the DRD5 gene: A preliminary study", AM J MED G, 96(5), 2000, pp. 654-658

Abstract

A pilot population-based study of a microsatellite polymorphism at the DRD5 locus in adult European-Americans showed its association with childhood symptom counts for oppositional defiant disorder (ODD) in males and females and adult antisocial personality disorder (ASPD) in females. No associationwith childhood conduct disorder symptom count was observed. ODD mediated the genotype-ASPD relationship in females. Neither ODD nor ASPD significantly mediated the relationship between the genotype and the liability to substance dependence (SD). The data suggest involvement of the DRD5 locus in thevariation and sexual dimorphism of SD liability and antisociality and in the developmental continuity of antisociality. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:654-658, 2000. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/21 alle ore 07:06:44