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Titolo:
Confirmation of an excess of the high enzyme activity COMT val allele in heroin addicts in a family-based haplotype relative risk study
Autore:
Horowitz, R; Kotler, M; Shufman, E; Aharoni, S; Kremer, I; Cohen, H; Ebstein, RP;
Indirizzi:
S Herzog Mem Hosp, Res Lab, IL-91351 Jerusalem, Israel S Herzog Mem Hosp Jerusalem Israel IL-91351 , IL-91351 Jerusalem, Israel Ben Gurion Univ Negev, Fac Hlth Sci, Beersheva Mental Hlth Ctr, Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel al Hlth Ctr, Beer Sheva, Israel Jerusalem Inst Treatment Subst Abuse, Jerusalem, Israel Jerusalem Inst Treatment Subst Abuse Jerusalem Israel Jerusalem, Israel
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 5, volume: 96, anno: 2000,
pagine: 599 - 603
SICI:
0148-7299(20001009)96:5<599:COAEOT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CATECHOL-O-METHYLTRANSFERASE; DEPENDENT DIABETES-MELLITUS; HYPERACTIVITY DISORDER ADHD; CYCLING BIPOLAR DISORDER; QUANTITATIVE TRAIT LOCI; ALCOHOL DEPENDENCE; DRUG-ABUSE; ASSOCIATION; SCHIZOPHRENIA; POLYMORPHISM;
Keywords:
catechol O-methyltransferase; polymorphism; substance abuse; heroin; haplotype relative risk; allele frequency;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Ebstein, RP S Herzog Mem Hosp, Res Lab, POB 35300, IL-91351 Jerusalem, Israel S Herzog Mem Hosp POB 35300 Jerusalem Israel IL-91351 Israel
Citazione:
R. Horowitz et al., "Confirmation of an excess of the high enzyme activity COMT val allele in heroin addicts in a family-based haplotype relative risk study", AM J MED G, 96(5), 2000, pp. 599-603

Abstract

A previous case control study by Vandenbergh et al. [1997: Am J Med Genet 74:439-442] showed an association between the high activity catechol O-methyltransferase (COMT) polymorphism and polysubstance abuse in a group of North American subjects, In the current study we confirm these results by genotyping 38 Israeli heroin addicts and both parents using a robust family-based haplotype relative risk (HRR) strategy. There is an excess of the val COMT allele (likelihood ratio = 4.48, P = 0.03) and a trend for an excess of the val/val COMT genotype (likelihood ratio = 4.97, P = 0.08, 2 df) in the heroin addicts compared to the HRR control group. We also genotyped an additional 101 nonrelated heroin addicts and 126 control subjects using a case control design and found no significant difference in COMT val allele frequency (25.4% vs. 29.7%, likelihood ratio = 1.04, P = 0.31). A significant difference is observed in COMT allele frequency among the three principal Israeli ethnic groups (Ashkenazi Jewish, non-Ashkenazi Jewish, and PalestinianArab) in a large group of control subjects we have so far examined (chi-square = 7.9, P = 0.019, df = 2, n = 1,422 alleles) suggesting that population stratification is responsible for our failure to observe an excess of theCOMT vol allele when using the case-control design. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:599-603, 2000. (C) 2000 Wiley-Liss, Inc.

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Documento generato il 09/04/20 alle ore 13:28:08