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Titolo:
Oral delivery of salmon calcitonin
Autore:
Lee, YH; Sinko, PJ;
Indirizzi:
Rutgers State Univ, Coll Pharm, Dept Pharmaceut, Piscataway, NJ 08854 USA Rutgers State Univ Piscataway NJ USA 08854 ceut, Piscataway, NJ 08854 USA
Titolo Testata:
ADVANCED DRUG DELIVERY REVIEWS
fascicolo: 3, volume: 42, anno: 2000,
pagine: 225 - 238
SICI:
0169-409X(20000831)42:3<225:ODOSC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEPTIDE DRUGS; POLYACRYLIC POLYMERS; ABSORPTION ENHANCERS; PULMONARY DELIVERY; THERAPEUTIC USE; OSTEOPOROSIS; RATS; PH; SYSTEMS; COLON;
Keywords:
salmon calcitonin; permeability; oral absorption; bioavailability;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Sinko, PJ Rutgers State Univ, Coll Pharm, Dept Pharmaceut, 160 Frelinghuysen Rd, Piscataway, NJ 08854 USA Rutgers State Univ 160 Frelinghuysen Rd Piscataway NJ USA 08854
Citazione:
Y.H. Lee e P.J. Sinko, "Oral delivery of salmon calcitonin", ADV DRUG DE, 42(3), 2000, pp. 225-238

Abstract

Calcitonin plays a crucial role in both calcium homeostasis and bone remodeling, Establishing an oral delivery system for CT is of great importance since CT is currently administered only parenterally or nasally. Poor absorption and rapid proteolytic degradation have impeded the clinical development of an orally administered sCT drug product. Potential approaches to enhance sCT absorption include the use of formulation additives in the drug product to transiently modulate the intestinal environment ol targeting specific intestinal regions that may have favorable peptide delivery properties (e.g., low residual volume, high absorptive surface area or reduced enzymaticactivity). Potential approaches to limit the activity of intestinal enzymes include adjusting the pH of the intestinal contents to the pH minima of specific enzymes or maintaining high local drug concentrations in order to saturate enzyme systems. In this review, pharmacokinetic studies elucidatingthe rate-limiting steps fur achieving adequate sCT oral bioavailability are detailed, Further, several approaches for enhancing the oral absorption of sCT are presented. Specific emphasis is placed on regio-specific targeting (e.g., intestinal regional differences in dilution and spreading, etc.) and modulation of the intestinal environment (e.g., changing pH, etc.). The approaches are evaluated in in vitro and in vivo models. Finally, this paper closes with a brief section of concluding remarks. (C) 2000 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 12:53:00