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Titolo:
Relevance between striatal expression of Fos, proenkephalin mRNA, prodynorphin mRNA and rotation induced by l-stepholidine in 6-hydroxydopamine-lesioned rats
Autore:
Ding, YM; Tang, FM; Yu, LP; Fu, Y; Zhang, GY; Jin, GZ;
Indirizzi:
Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China Chinese Acad Sci Shanghai Peoples R China 200031 200031, Peoples R China Xuzhou Med Coll, Dept Biochem & Mol Biol, Xuzhou 221002, Peoples R China Xuzhou Med Coll Xuzhou Peoples R China 221002 ou 221002, Peoples R China
Titolo Testata:
ACTA PHARMACOLOGICA SINICA
fascicolo: 10, volume: 21, anno: 2000,
pagine: 885 - 892
SICI:
0253-9756(200010)21:10<885:RBSEOF>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA LEVELS; DOPAMINE RECEPTOR ANTAGONISTS; GENE-EXPRESSION; LESIONED RATS; ADULT-RATS; DYNORPHIN; BEHAVIOR; NEURONS; D2; ENKEPHALIN;
Keywords:
stepholidine; corpus striatum; 6-hydroxydopamine; in situ hybridization; gene expression; enkephalins; dynorphins; fos genes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Jin, GZ Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China Chinese Acad Sci Shanghai Peoples R China 200031 Peoples R China
Citazione:
Y.M. Ding et al., "Relevance between striatal expression of Fos, proenkephalin mRNA, prodynorphin mRNA and rotation induced by l-stepholidine in 6-hydroxydopamine-lesioned rats", ACT PHAR SI, 21(10), 2000, pp. 885-892

Abstract

AIM: To study that l-stepholidine (SPD) regulates the expression of proenkephalin (PENK) and prodynorphin (PDYN) mRNA and Fos in the striatum after rotational test in the 6-hydroxydopamine (6-OHDA)-lesioned rats. METHODS: PENK and PDYN mRNA levels were examined with in situ hybridization, and Fos expression was detected with immunocytochemistry. The data were semi-quantified with image analyzer. RESULTS: (1) Following repeated SPD treatment, therotation was kept on high activity in the 6-OHDA-lesioned rats. (2) SPD significantly elicited Fos expression in both sides of striatum, particularlyin the denervated one. Repeated administration of SPD, Fos expression declined on both sides, particularly in the intact one. (3) In the denervated striatum of 6-OHDA-lesioned rats, the PENK mRNA level was extremely increased vs that in the intact striatum. This high level of PENK mRNA was significantly reduced by 7-d treatments of SPD. SPD also reduced the level of PENK mRNA in the intact striatum. However, the level of PDYN mRNA did not show significant change in both sides of striatum after denervation or SPD treatment. CONCLUSION: In the 6-OHDA-lesioned rats, the rotation induced by SPD was kept on a high activity, which was in pace with the inducement of Fos expression and the reduction of expression of PENK mRNA in the denervated striatum. But then the lesion and SPD treatment had no remarkable effect on the expression of PDYN mRNA.

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Documento generato il 06/04/20 alle ore 07:19:12