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Titolo:
Expression of OX40 and OX40 ligand (gp34) in the normal and myasthenic thymus
Autore:
Onodera, J; Nagata, T; Fujihara, K; Ohuchi, M; Ishii, N; Sugamura, K; Itoyama, Y;
Indirizzi:
Tohoku Univ, Sch Med, Dept Neurol, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ, Sch Med, Dept Microbiol & Immunol, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan Sendai Natl Hosp, Div Thorac & Cardiovasc Surg, Sendai, Miyagi, Japan Sendai Natl Hosp Sendai Miyagi Japan diovasc Surg, Sendai, Miyagi, Japan Tohoku Welf Pens Hosp, Div Neurol, Sendai, Miyagi, Japan Tohoku Welf Pens Hosp Sendai Miyagi Japan Neurol, Sendai, Miyagi, Japan
Titolo Testata:
ACTA NEUROLOGICA SCANDINAVICA
fascicolo: 4, volume: 102, anno: 2000,
pagine: 236 - 243
SICI:
0001-6314(200010)102:4<236:EOOAOL>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL ACTIVATION; VIRUS TYPE-I; ACETYLCHOLINE-RECEPTOR; GRAVIS; LYMPHOCYTES; ANTIGEN; DIFFERENTIATION; IDENTIFICATION; PROLIFERATION; CYTOKINES;
Keywords:
myasthenia gravis; thymus; OX40; OX40 ligand; gp34; immunocytochemistry; flowcytometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Fujihara, K Tohoku Univ, Sch Med, Dept Neurol, Aoba Ku, 1-1 Seiryo Machi, Sendai, Miyagi 9808574, Japan Tohoku Univ 1-1 Seiryo Machi Sendai Miyagi Japan 9808574 Japan
Citazione:
J. Onodera et al., "Expression of OX40 and OX40 ligand (gp34) in the normal and myasthenic thymus", ACT NEUR SC, 102(4), 2000, pp. 236-243

Abstract

To examine the expression of OX40, an activated memory T-cell marker, and its ligand (OX40L), a set of molecules for T-cell-B-cell interaction, and other lymphocyte activation markers in the thymuses of myasthenia gravis (MG) and controls. Material and methods - We studied the expression of OX40, OX40L, IL-2R alpha and HLA-DR in the thymic tissues of MG and controls usingimmunocytochemistry and flowcytometry. Results - In both hyperplastic thymus of MG and control thymus, OX40(+) cells were scattered mainly in the medulla with much fewer OX40L(+) cells being distributed in the corticomedullary junctions. IL-2R alpha and HLA-DR were expressed in the medulla at higher frequencies as compared with OX40 in controls as well as MG. In contrast,the numbers of OX40(+) cells around the germinal centers (GC) were significantly greater than those of control thymuses, and some mononuclear cells in CC were OX40L(+). A considerable number of OX40(+) cells were seen in thethymic tissues adjacent to thymomas. OX40 (+) cells were CD4(+) CD8(-) or CD4(+)CD8(+) and were mostly HLA-DR-. (The coexpression of OX40 and IL-2R alpha on activated CD4(+) T cells was previously reported. ) Conclusion - OX40, expressed in a fraction of activated CD4(+) T cells, may be upregulated in thymic tissues adjacent to GC and thymoma in MG, and OX40 may interact with OX40L in GC to enhance anti-acetylcholine receptor antibody production in MG.

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Documento generato il 06/07/20 alle ore 05:40:35