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Titolo:
Covalent inhibition of digestive lipases by chiral phosphonates
Autore:
Cavalier, JF; Buono, G; Verger, R;
Indirizzi:
ENSSPICAM, UMR 6516, F-13397 Marseille 20, France ENSSPICAM Marseille France 20 AM, UMR 6516, F-13397 Marseille 20, France CNRS, UPR 9025, Lab Lipolyse Enzymat, F-13402 Marseille, France CNRS Marseille France F-13402 ipolyse Enzymat, F-13402 Marseille, France
Titolo Testata:
ACCOUNTS OF CHEMICAL RESEARCH
fascicolo: 9, volume: 33, anno: 2000,
pagine: 579 - 589
SICI:
0001-4842(200009)33:9<579:CIODLB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOMOLECULAR FILM TECHNIQUE; CANDIDA-RUGOSA LIPASE; HUMAN GASTRIC LIPASE; PANCREATIC LIPASE; INTERFACIAL ACTIVATION; MICROBIAL LIPASES; STEREOSELECTIVE HYDROLYSIS; LIPOLYTIC ENZYMES; GLYCERIDE ANALOGS; KINETIC-ANALYSIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Buono, G ENSSPICAM, UMR 6516, Ave Escadrille Normandie Niemen, F-13397 Marseille 20, France ENSSPICAM Ave Escadrille Normandie Niemen Marseille France 20 ce
Citazione:
J.F. Cavalier et al., "Covalent inhibition of digestive lipases by chiral phosphonates", ACC CHEM RE, 33(9), 2000, pp. 579-589

Abstract

Designing and synthesizing specific inhibitors is of fundamental value forunderstanding the molecular mechanisms involved in the interfacial adsorption step as well as the catalytic activity of lipases. In this Account, we will review and discuss results obtained mostly at our laboratory concerning the covalent inhibition of human gastric and human pancreatic lipases by chiral phosphonates. Rather than presenting an exhaustive list of compoundstested so far with lipases of animal and microbial origin, we selected recent experimental data illustrating well the specific problems encountered during the covalent inhibition of these digestive lipases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 06:08:54