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Titolo:
Multifactorial protective mechanisms to limit viral replication in the lung of mice during primary murine cytomegalovirus infection
Autore:
Fernandez, JA; Rodrigues, EG; Tsuji, M;
Indirizzi:
NYU, Sch Med, Dept Med & Mol Parasitol, New York, NY 10010 USA NYU New York NY USA 10010 ept Med & Mol Parasitol, New York, NY 10010 USA
Titolo Testata:
VIRAL IMMUNOLOGY
fascicolo: 3, volume: 13, anno: 2000,
pagine: 287 - 295
SICI:
0882-8245(2000)13:3<287:MPMTLV>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERFERON-GAMMA; VIRUS-INFECTIONS; MCMV INFECTION; NK CELLS; T-CELL; ENHANCEMENT; RESPONSES; DISEASE; LIVER; ALPHA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Tsuji, M NYU, Sch Med, Dept Med & Mol Parasitol, 341 E 25th St,Room 302, New York, NY 10010 USA NYU 341 E 25th St,Room 302 New York NY USA 10010 rk, NY 10010 USA
Citazione:
J.A. Fernandez et al., "Multifactorial protective mechanisms to limit viral replication in the lung of mice during primary murine cytomegalovirus infection", VIRAL IMMUN, 13(3), 2000, pp. 287-295

Abstract

In this article, we investigated the protective host immune mechanisms against acute murine cytomegalovirus (MCMV) infection. For this purpose, we used various knockout mice lacking molecules, which include interferon-gamma (IFN-gamma), interferon-gamma receptor (IFN-gamma-R), interferon regulatoryfactor-1 (IRF-1), inducible nitric oxide synthase (iNOS), and perforin, Wealso used mutant mice lacking Fas molecule. When we infected these mice with MCMV and determined the viral titers in their lungs at different time points, we found that IFN-gamma, IFN-gamma-R, IRF-1, iNOS, and perforin-deficient mice developed significantly higher titers of infectious MCMV in the lung, compared to those observed in their respective wild-type controls. In the lungs of Fas-mutant mice, viral titers were similar to those obtained in wild-type mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 09:59:21