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Titolo:
The immune system as a potential target for environmental estrogens (endocrine disrupters): a new emerging field
Autore:
Ahmed, SR;
Indirizzi:
Virginia Polytech Inst & State Univ, Virginia Maryland Reg Coll Vet Med, Dept Biomed Sci & Pathobiol, Ctr Mol Med & Infect Dis, Blacksburg, VA 24060 USA Virginia Polytech Inst & State Univ Blacksburg VA USA 24060 VA 24060 USA
Titolo Testata:
TOXICOLOGY
fascicolo: 1-3, volume: 150, anno: 2000,
pagine: 191 - 206
SICI:
0300-483X(20000907)150:1-3<191:TISAAP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADULT MALE-RATS; LUPUS-ERYTHEMATOSUS; SEX-HORMONES; AUTOIMMUNE-DISEASES; POLYCHLORINATED-BIPHENYLS; ORGANOCHLORINE COMPOUNDS; AUTOANTIBODY PRODUCTION; CYTOKINE PRODUCTION; MURINE SPLENOCYTES; GONADAL-STEROIDS;
Keywords:
immune; autoimmune; estrogens; environmental estrogens; endocrine disrupters; allergies;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
116
Recensione:
Indirizzi per estratti:
Indirizzo: Ahmed, SR Virginia Polytech Inst & State Univ, Virginia Maryland Reg Coll Vet Med, Dept Biomed Sci & Pathobiol, Ctr Mol Med & Infect Dis, 1410 PricesFork Rd, Blacksburg, VA 24060 USA Virginia Polytech Inst & State Univ 1410Prices Fork Rd Blacksburg VA USA 24060
Citazione:
S.R. Ahmed, "The immune system as a potential target for environmental estrogens (endocrine disrupters): a new emerging field", TOXICOLOGY, 150(1-3), 2000, pp. 191-206

Abstract

It is now well known that natural (17 beta-estradiol) and synthetic (e.g. diethylstilbestrol) estrogens not only affect the reproductive system, but also markedly influence the immune system. Recently, a new class of estrogens that is abundant in the environment (in industrial chemicals, pesticides, and surfactants) has been recognized. Some of these estrogenic chemicals (which are a large subgroup of endocrine disrupters) have also been shown to influence the immune system. This review assimilates growing evidence in wildlife, laboratory animals and to a limited extent in humans, which suggests that environmental chemicals may also affect the immune system. Furtherstudies are needed to ascertain the immunological consequences of exposureto environmental estrogens, especially in humans. At the present time, it is not known whether the human immune system responds to a low dose of environmental estrogens or if environmental estrogens influence certain subsetsof human populations, rather than the general population. Conceivably, an alteration of the immune system by environmental estrogens could affect theindividuals' ability to mount well-regulated immune responses to microbialand vaccine antigens, allergens, self and tumor antigens. Possible changesin the immune system must be investigated routinely in toxicity studies. Acomprehensive mechanistic understanding of potential immunomodulatory chemicals is needed. In this regard, relevant laboratory animals may be especially useful in identifying susceptible periods of life, whether both gendersare equally affected, in analysis of changes in target lymphoid organs, and to determine the immunological effects of mixtures of chemicals. (C) 2000Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 01:13:09