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Titolo:
Effects of intermittent hypoxia on the isocapnic hypoxic ventilatory response and erythropoiesis in humans
Autore:
Garcia, N; Hopkins, SR; Powell, FL;
Indirizzi:
Univ Paris 13, UFR Med, Lab Reponses Cellulaires & Fonct Hypoxie, F-93012 Bobigny, France Univ Paris 13 Bobigny France F-93012 ct Hypoxie, F-93012 Bobigny, France Univ Calif San Diego, Dept Med 0623A, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 0623A, La Jolla, CA 92093 USA Univ Calif San Diego, White Mtn Res Stn, La Jolla, CA 92093 USA Univ CalifSan Diego La Jolla CA USA 92093 es Stn, La Jolla, CA 92093 USA
Titolo Testata:
RESPIRATION PHYSIOLOGY
fascicolo: 1-2, volume: 123, anno: 2000,
pagine: 39 - 49
SICI:
0034-5687(200010)123:1-2<39:EOIHOT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
RIGHT VENTRICULAR HYPERTROPHY; HIGH-ALTITUDE; POIKILOCAPNIC HYPOXIA; RESPIRATORY CONTROL; HYPOBARIC HYPOXIA; PRE-ADAPTATION; EXPOSURE; PREACCLIMATIZATION; EXERCISE; EVEREST;
Keywords:
Blood, O-2 transport, hypoxia; control of breathing, hypoxic ventilatory response; hypoxia, intermittent, ventilatory response, blood O-2 transport; mammals, human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Garcia, N Univ Paris 13, UFR Med, Lab Reponses Cellulaires & Fonct Hypoxie, F-93012 Bobigny, France Univ Paris 13 Bobigny France F-93012 , F-93012 Bobigny, France
Citazione:
N. Garcia et al., "Effects of intermittent hypoxia on the isocapnic hypoxic ventilatory response and erythropoiesis in humans", RESP PHYSL, 123(1-2), 2000, pp. 39-49

Abstract

Isocapnic hypoxic ventilatory response (HVR) and hematological variables were measured in nine adult males (age: 29.3 +/- 3.4) exposed to normobaric intermittent hypoxia (IH, 7 h daily at FIO2 = 0.13, equivalent to 3800 m altitude) for 12 days. hlean HVR significantly increased during IH, however,after reaching a peak on Day 5 (0.79 +/- 0.12 vs. 0.27 +/- 0.11 L(.)min(-1) (.)%(-1) on Day 1, P < 0.05), it progressively decreased toward a lower value (0.46 +/- 0.16 L min(-1) (.)%(-1) on Day 12). In contrast, the subjects showed no changes in the ventilatory data and arterial O-2-saturation in normoxia or poikilocapnic hypoxia (PETCO2 uncontrolled). Hematocrit and hemoglobin concentration did not change, but the reticulocyte count increased by Day 5 (P < 0.01). Our results suggest that moderate intermittent hypoxiainduces changes in ventilatory O-2-sensitivity and triggers the hematological acclimatization by increasing the percentage of reticulocytes in the blood. Normal ventilatory acclimatization to hypoxia was, however, not observed and the mechanisms involved in the biphasic changes in HVR we observed remain to be determined. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 06/06/20 alle ore 17:45:50