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Titolo:
Metabolism and functions of glutathione in brain
Autore:
Dringen, R;
Indirizzi:
Univ Tubingen, Inst Physiol Chem, D-72076 Tubingen, Germany Univ TubingenTubingen Germany D-72076 l Chem, D-72076 Tubingen, Germany
Titolo Testata:
PROGRESS IN NEUROBIOLOGY
fascicolo: 6, volume: 62, anno: 2000,
pagine: 649 - 671
SICI:
0301-0082(200012)62:6<649:MAFOGI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-GLUTAMYL-TRANSPEPTIDASE; CENTRAL-NERVOUS-SYSTEM; CULTURED ASTROGLIAL CELLS; HYDROGEN-PEROXIDE TOXICITY; EXTRACELLULAR REDUCED GLUTATHIONE; DEPLETED MESENCEPHALIC CULTURES; PRIMARY ASTROCYTE CULTURES; PEPTIDE TRANSPORTER PEPT2; PROTECTS DOPAMINE NEURONS; ISOLATED RAT HEPATOCYTES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
303
Recensione:
Indirizzi per estratti:
Indirizzo: Dringen, R Univ Tubingen, Inst Physiol Chem, Hoppe Seyler Str 4, D-72076 Tubingen, Germany Univ Tubingen Hoppe Seyler Str 4 Tubingen Germany D-72076many
Citazione:
R. Dringen, "Metabolism and functions of glutathione in brain", PROG NEUROB, 62(6), 2000, pp. 649-671

Abstract

The tripeptide glutathione is the thiol compound present in the highest concentration in cells of all organs. Glutathione has many physiological functions including its involvement in the defense against reactive oxygen species. The cells of the human brain consume about 20% of the oxygen utilized by the body but constitute only 2% of the body weight. Consequently, reactive oxygen species which are continuously generated during oxidative metabolism will be generated in high rates within the brain. Therefore. the detoxification of reactive oxygen species is an essential task within the brain and the involvement of the antioxidant glutathione in such processes is veryimportant. The main focus of this review article will be recent results onglutathione metabolism of different brain cell types in culture. The glutathione content of brain cells depends strongly on the availability of precursors for glutathione. Different types of brain cells prefer different extracellular glutathione precursors. Glutathione is involved in the disposal of peroxides by brain cells and in the protection against reactive oxygen species. In coculture astroglial cells protect other neural cell types against the toxicity of various compounds. One mechanism for this interaction is the supply by astroglial cells of glutathione precursors to neighboring cells. Recent results confirm the prominent role of astrocytes in glutathione metabolism and the defense against reactive oxygen species in brain. These results also suggest an involvement of a compromised astroglial glutathionesystem in the oxidative stress reported for neurological disorders. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:09:24