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Titolo:
PTSD-related hyperarousal assessed during sleep
Autore:
Woodward, SH; Murburg, MM; Bliwise, DL;
Indirizzi:
VA Palo Alto Hlth Care Syst, Natl Ctr PTSD, Clin Lab, Palo Alto, CA 94304 USA VA Palo Alto Hlth Care Syst Palo Alto CA USA 94304 alo Alto, CA 94304 USA VA Palo Alto Hlth Care Syst, Educ Div, Palo Alto, CA 94304 USA VA Palo Alto Hlth Care Syst Palo Alto CA USA 94304 alo Alto, CA 94304 USA Univ Washington, Sch Med, Dept Psychiat, Seattle, WA USA Univ Washington Seattle WA USA , Sch Med, Dept Psychiat, Seattle, WA USA Emory Univ, Sch Med, Sleep Disorders Clin, Atlanta, GA USA Emory Univ Atlanta GA USA Sch Med, Sleep Disorders Clin, Atlanta, GA USA
Titolo Testata:
PHYSIOLOGY & BEHAVIOR
fascicolo: 1-2, volume: 70, anno: 2000,
pagine: 197 - 203
SICI:
0031-9384(20000701)70:1-2<197:PHADS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTTRAUMATIC-STRESS-DISORDER; VIETNAM COMBAT VETERANS; LOCUS-COERULEUS; DISTURBANCE; NEURONS; BRAIN; OSCILLATIONS; THRESHOLDS; DEPRESSION; INPATIENTS;
Keywords:
hyperarousal; REM sleep; PTSD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Woodward, SH VA Palo Alto Hlth Care Syst, Natl Ctr PTSD, Clin Lab, Palo Alto, CA 94304 USA VA Palo Alto Hlth Care Syst Palo Alto CA USA 94304 94304 USA
Citazione:
S.H. Woodward et al., "PTSD-related hyperarousal assessed during sleep", PHYSL BEHAV, 70(1-2), 2000, pp. 197-203

Abstract

Posttraumatic stress disorder is widely understood to include "persistent symptoms of increased arousal. " This presumption has rarely been tested under conditions in which effects of anticipatory anxiety could be ruled out. Zn this study, heart rate and electroencephalogram spectral power were assessed during sleep, a state free of most sources of artifact contaminating indices of tonic arousal. Fifty-six unmedicated nonapneic Vietnam combat-related inpatients with posttraumatic stress disorder (PTSD) and 14 controls spent 3 or more nights in the sleep laboratory during which their electrocardiograms and electroencephalograms were continuously recorded. Heart rate and electroencephalogram spectral power were quantified continuously off-line and averaged by sleep stage over all postadaptational nights. Sleep heartrate exhibited no group differences and no covariation with the severity of subjective hyperarousal reported by PTSD patients. PTSD patients exhibited a trend toward reduced low-frequency electroencephalogram spectral power during nonrapid-eye-movement (NREM) sleep. This reduction was significant during slow-wave sleep in those subjects producing scoreable slow-wave sleep. The relationship of rapid-eye-movement (REM) beta-band power to NREM beta-band power was different in PTSD patients and controls, with the patients exhibiting more beta in REM versus NREM sleep than controls. In patients, NREM sleep sigma-band electroencephalogram spectral power exhibited a positive correlation with subjective hyperarousal. Finally, a novel and surprisingly strong inverse correlation between REM-NREM sleep heart rate differenceand REM percent of sleep was observed in PTSD patients only. In summary, peripheral and central measures of tonic arousal during sleep demonstrated contrastive relations to PTSD diagnostic and symptom status. The data suggest that more consideration should be directed to mechanisms of central arousal in PTSD. (C) 2000 Elsevier Science Inc. All rights reserved.

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Documento generato il 05/04/20 alle ore 12:47:16