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Titolo:
Comparison of conformal radiation therapy techniques within the dynamic radiotherapy project 'Dynarad'
Autore:
Mavroidis, P; Lind, BK; Van Dijk, J; Koedooder, K; De Neve, W; De Wagter, C; Planskoy, B; Rosenwald, JC; Proimos, B; Kappas, C; Claudia, D; Benassi, M; Chierego, G; Brahme, A;
Indirizzi:
Karolinska Inst, Dept Med Radiat Phys, S-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17176 Phys, S-17176 Stockholm, Sweden Stockholm Univ, S-17176 Stockholm, Sweden Stockholm Univ Stockholm Sweden S-17176 Univ, S-17176 Stockholm, Sweden Univ Amsterdam, Acad Med Ctr, Dept Radiotherapy, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands State Univ Ghent Hosp, Div Radiotherapy, B-9000 Ghent, Belgium State Univ Ghent Hosp Ghent Belgium B-9000 herapy, B-9000 Ghent, Belgium Univ Coll London, Dept Med Phys & Bioengn, London, England Univ Coll London London England ept Med Phys & Bioengn, London, England Middlesex Hosp, Dept Radiotherapy, London, England Middlesex Hosp LondonEngland Hosp, Dept Radiotherapy, London, England Inst Curie, Dept Med Phys, Paris, France Inst Curie Paris FranceInst Curie, Dept Med Phys, Paris, France Univ Patras, Sch Med, Dept Med Phys, GR-26110 Patras, Greece Univ Patras Patras Greece GR-26110 ept Med Phys, GR-26110 Patras, Greece Regina Elena Natl Canc Inst Rome, Lab Med Phys, Rome, Italy Regina Elena Natl Canc Inst Rome Rome Italy , Lab Med Phys, Rome, Italy Borgo Trento Hosp, Dept Med Phys, Verona, Italy Borgo Trento Hosp VeronaItaly rento Hosp, Dept Med Phys, Verona, Italy St Bartholomews Hosp, Dept Radiotherapy, London, England St Bartholomews Hosp London England Dept Radiotherapy, London, England
Titolo Testata:
PHYSICS IN MEDICINE AND BIOLOGY
fascicolo: 9, volume: 45, anno: 2000,
pagine: 2459 - 2481
SICI:
0031-9155(200009)45:9<2459:COCRTT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BEAM PROFILES; TUMOR-CONTROL; NORMAL TISSUE; OPTIMIZATION; VOLUME; PROBABILITY; TOLERANCE; TARGET; NECK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Mavroidis, P Karolinska Inst, Dept Med Radiat Phys, POB 260, S-17176 Stockholm, Sweden Karolinska Inst POB 260 Stockholm Sweden S-17176 olm, Sweden
Citazione:
P. Mavroidis et al., "Comparison of conformal radiation therapy techniques within the dynamic radiotherapy project 'Dynarad'", PHYS MED BI, 45(9), 2000, pp. 2459-2481

Abstract

The objective of the dynamic radiotherapy project 'Dynarad' within the European Community has been to compare and grade treatment techniques that arecurrently applied or being developed at the participating institutions. Cervical cancer was selected as the tumour site on the grounds that the involved organs at risk, mainly the rectum and the bladder, are very close to the tumour and partly located inside the internal target volume. In this work, a solid phantom simulating the pelvic anatomy was used by institutions inBelgium, France, Greece, Holland, Italy, Sweden and the United Kingdom. The results were evaluated using both biological and physical criteria. The main purpose of this parallel evaluation is to test the value of biological and physical evaluations in comparing treatment techniques. It is demonstrated that the biological objective functions allow a much higher conformality and a more clinically relevant scoring of the outcome. Often external beam treatment techniques have to be combined with intracavitary therapy to give clinically acceptable results. However, recent developments can reduce or even eliminate this need by delivering more conformal dose distributions using intensity modulated external dose delivery. In these cases the reliability of the patient set-up procedure becomes critical for the effectiveness of the treatment.

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Documento generato il 28/11/20 alle ore 18:51:08