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Titolo:
Suppression of conditioned fear by administration of CRF receptor antagonist CP-154,526
Autore:
Hikichi, T; Akiyoshi, J; Yamamoto, Y; Tsutsumi, T; Isogawa, K; Nagayama, H;
Indirizzi:
Oita Med Univ, Dept Neuropsychiat, Oita 8755593, Japan Oita Med Univ Oita Japan 8755593 Dept Neuropsychiat, Oita 8755593, Japan
Titolo Testata:
PHARMACOPSYCHIATRY
fascicolo: 5, volume: 33, anno: 2000,
pagine: 189 - 193
SICI:
0176-3679(200009)33:5<189:SOCFBA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; IMPAIRED STRESS-RESPONSE; RAT-BRAIN; ANXIETY DISORDERS; FACTOR NEURONS; ACTIVATION; MICE; WITHDRAWAL; ALPRAZOLAM; AMYGDALA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Akiyoshi, J Oita Med Univ, Dept Neuropsychiat, Oita 8755593, Japan Oita Med Univ Oita Japan 8755593 ychiat, Oita 8755593, Japan
Citazione:
T. Hikichi et al., "Suppression of conditioned fear by administration of CRF receptor antagonist CP-154,526", PHARMACOPS, 33(5), 2000, pp. 189-193

Abstract

In order to examine the involvement of corticotropin-releasing hormone (CRF) receptor in the formation of anxiety, we investigated whether CRF receptor antagonist CP-154,526 suppressed conditioned fear stress. First, rats were individually subjected to 30 min of footshock. Twenty-four hours after footshock, the rats were again placed in the chamber and observed for 5 min without shock. CP-154,526 was administered 30 min before placing the rats in the chamber again. After that, CP-154,526 was once more administered 30 min before applying footshock. Administration of CP-154,526 30 min both before conditioned fear stress (placing the rats inside the cage but not applying footshock) and before actual footshock significantly reduced freezing behavior. These results show that CP-154,526 blocked both the acquisition andexpression of conditioned fear, thus suggesting that the CRF receptor might be related to anxiety.

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Documento generato il 21/09/20 alle ore 16:09:03